Motor neuron involvement in a patient with long-term corticosteroid administration

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概要

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• An asthmatic patient with corticosteroid treatment for 45 years presented with slowly progressive limb muscle atrophy. His muscle symptoms were involved in four limbs and tongue, and deep tendon reflexes were exaggerated. Biopsied muscle pathology indicated the presence of neurogenic muscular atrophy in combination with corticosteroid myopathy. Furthermore, 8-hydroxy-deoxyguanosine (8-OH-dG) was prominently increased in mitochondrial and nuclear DNA. An aerobic exercise test demonstrated remarkable serum lactate elevation, which was attenuated by the administration of coenzyme Q10- These findings are consistent with the assumption that long-term corticosteroid administration potentially induces not only myopathy but also motor neuron involvement as in mitochondrial diseases.(Internal Medicine 42: 862-866, 2003)

• 社団法人 日本内科学会の論文
• 2003-09-01

著者

• Odomi Masaaki

  Analytical Department Formulation Research Institute Otsuka Pharmaceutical Co. Ltd.

• Mitsui Takao

  First Department Of Internal Medicine School Of Medicine The University Of Tokushima

• MATSUMOTO Toshio

  the First Department of Internal Medicine

• AKI Kenji

  Institute for Enzyme Research, The University of Tokushima

• Ohtsuka Satoshi

  First Department Of Internal Medicine School Of Medicine The University Of Tokushima

• Umaki Yoshifumi

  First Department Of Internal Medicine School Of Medicine The University Of Tokushima

• Nagasawa Masakazu

  Analytical Department Formulation Research Institute Otsuka Pharmaceutical Co. Ltd.

• Akaike Masashi

  First Department Of Internal Medicine School Of Medicine The University Of Tokushima

• Matsumoto Toshio

  The First Department Of Internal Medicine School Of Medicine The University Of Tokushima

• Aki Kenji

  Institute For Enzyme Research The University Of Tokushima

• Akaike M

  First Department of Internal Medicine, University of Tokyshima School of Medicine

• Ohtsuka S

  First Department of Internal Medicine, School of Medicine, The University of Tokushima

• Odomi M

  Analytical Department, Formulation Research Institute, Otsuka Pharmaceutical Co., Ltd.

• Aki K

  Institute for Enzyme Research, The University of Tokushima

• Matsumoto T

  the First Department of Internal Medicine, School of Medicine, The University of Tokushima

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