Multifocal Conduction Blocks in Sarcoid Peripheral Neuropathy

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概要

• 論文の詳細を見る

• Peripheral neuropathy is a rare manifestation of sarcoidosis, and previous studies have shown axonal degeneration as the main pathology. We herein report three patients with sarcoidosis who presented with multiple mononeuropathy as the initial manifestation. Nerve conduction studies showed prominent multifocal conduction blocks in the intermediate nerve trunk. In all three patients, corticosteroid treatment resulted in a dramatic clinical improvement associated with rapid resolution of conduction blocks. The sequential electrodiagnostic findings suggest that demyelinative or ischemic-functional conduction block is responsible for their neuropathy. To date, only three cases of acute conduction block neuropathy associated with sarcoidosis have been reported, but it may occur more frequently than expected.

著者

• Kuwabara Satoshi

  Department Of Neurology Chiba University

• Koga Shunsuke

  Department Of Allergy And Clinical Immunology Chiba University Hospital

• Kanai Kazuaki

  Department Of Neurology Graduate School Of Medicine Chiba University

• Sekiguchi Yukari

  Department Of Anatomy And Embryology Faculty Of Medicine University Of Tsukuba

• Kobayashi Makoto

  Department Of Agricultural Chemistry College Of Agriculture And Veterinary Medicine Nihon University

• Misawa Sonoko

  Department of Neurology, Chiba University School of Medicine

• Koga Shunsuke

  Departments of Neurology, Graduate School of Medicine, Chiba University

• Sawai Setsu

  Departments of Neurology, Graduate School of Medicine, Chiba University

• Isose Sagiri

  Departments of Neurology, Graduate School of Medicine, Chiba University

• Shibuya Kazumoto

  Departments of Neurology, Graduate School of Medicine, Chiba University

• Nasu Saiko

  Departments of Neurology, Graduate School of Medicine, Chiba University

• Noto Yuichi

  Departments of Neurology, Graduate School of Medicine, Chiba University

• Fujimaki Yumi

  Departments of Neurology, Graduate School of Medicine, Chiba University

• Ohtani Ryohei

  Departments of Neurology, Graduate School of Medicine, Chiba University

• Nasu Saiko

  Department of Neurology, Graduate School of Medicine, Chiba University, Japan

• Fujimaki Yumi

  Department of Neurology, Graduate School of Medicine, Chiba University, Japan

• Shibuya Kazumoto

  Department of Neurology, Graduate School of Medicine, Chiba University, Japan

• Isose Sagiri

  Department of Neurology, Graduate School of Medicine, Chiba University, Japan

• Kanai Kazuaki

  Department of Applied Chemistry, Faculty of Science and Technology, Keio University

• Kuwabara Satoshi

  Departments of Neurology, Graduate School of Medicine, Chiba University

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