Regular Exercise Improves Insulin Sensitivity, Physical Activity, and Psychosocial Status in Patients with Chronic Liver Diseases

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概要

• 論文の詳細を見る

• Limitations to physical activity lead to impairments of insulin sensitivity and deterioration of health related quality of life (HRQOL) in patients with chronic liver diseases (CLD). The effects of regular exercise on physical and psychosocial factors were prospectively evaluated in CLD. Five patients with various etiologies and stages were enrolled. Daily aerobic and resistance trainings were conducted for a course of five months with an oral intake of branched-chain amino acids (BCAA) starting one month prior to the exercise. Various biochemical, physical parameters, and profile of mood states (POMS) were measured before and after the course. Statistical significance was evaluated using a resampling method. No event was marked during the course to require additional treatments. A significant improvement in insulin sensitivity was observed as reductions of fasting blood glucose and serum insulin levels. Physical capability was significantly improved in both strength and endurance as increments of grasping and knee extension powers, and ventilatory threshold. The fatigue score was significantly reduced in accordance with a decreasing tendency of all other negative aspects in POMS. While significant decreases in serum concentrations of cholinesterase and prealbumin, platelet count, and bone mass were observed, serum concentrations of transferrin and BCAA as well as prothrombin activity showed increasing tendency. Regular exercise could be a promising alternative to improve insulin sensitivity and HRQOL in CLD, though medications and close evaluation should be conducted for possibilities of osteoporosis and hemorrhagic events.

• 新潟大学の論文

著者

• KOBAYASHI Makoto

  Department of Machine Intelligence and Systems Engineering, Graduate School of Engineering, Tohoku U

• ARAKAWA Masaaki

  Niigata Health Promotion Center, Niigata Institute of Sports Medicine and Science

• Arakawa M

  Division Of Respiratory Medicine Niigata University Graduate School Of Medical And Dental Sciences

• Aoyagi Yutaka

  Department Of Third Internal Medicine Niigata University School Of Medicine

• Aoyagi Y

  The Third Division Department Of Internal Medicine Niigata University School

• Aoyagi Yutaka

  Department Of Radiology Tokyo Dental College

• Arakawa Masaaki

  Niigata Health Promotion And Sports Medicine Center

• NOMOTO Minoru

  Departments of Molecular Biology, School of Medicine, University of Occupational and Environmental H

• Aoyagi Yutaka

  新潟大学 医歯学総合研究科消化器内科学

• Arakawa Masaaki

  新潟大学 医歯学総合研究科呼吸器内科

• SUDA Takeshi

  Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niiga

• HASIBA Masao

  Niigata Health Promotion and Sports Medicine Center

• NAGASAKI Koji

  Niigata Health Promotion and Sports Medicine Center

• ADACHI Aiko

  Niigata Health Promotion and Sports Medicine Center

• Suda Takeshi

  Division Of Gastroenterology And Hepatology Niigata University Graduate School Of Medical And Dental

• Suda Takeshi

  Department Of Bioinformatics Soka University

• Nomoto M

  Department Of Gastroenterology And Hepatology Graduate School Of Medical And Dental Sciences Niigata

• Nomoto Minoru

  Department Of Gastroenterology Niigata University Graduate School Of Medical And Dental Sciences

• Nomoto Minoru

  Department Of Internal Medicine Iii Niigata University School Of Medicine

• Kobayashi Makoto

  Department Of Gastroenterology And Hepatology Division Of Clinical Medicine And Biomedical Science I

• Aoyagi Yutaka

  Department Of Gastroenterology And Hepatology Niigata University Graduate School Of Medical And Dent

• Kobayashi Makoto

  Department Of Gastroenterology And Hepatology Graduate School Of Medical And Dental Sciences Niigata

• Nomoto Minoru

  Department Of Gastroenterology And Hepatology Graduate School Of Medical And Dental Sciences Niigata

• Aoyagi Yutaka

  Third Department Of Internal Medicine Niigata University School Of Medicine

• HASHIBA Masao

  Niigata Institute for Health and Sports Medicine

• Kobayashi Makoto

  Department Of Agricultural Chemistry College Of Agriculture And Veterinary Medicine Nihon University

• Suda Takeshi

  Department of Applied Chemistry, Faculty of Engineering, Tohoku University

• Hashiba Masao

  Niigata Health Promotion and Sports Medicine Center

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