Involvement of Drosophila Sir2-like genes in the regulation of life span
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概要
- 論文の詳細を見る
In Drosophila melanogaster, the Sir2 gene and four Sir2-like genes have been found to be homologous to yeast SIR2 genes. To examine whether the fly Sir2, CG5216, and two Sir2-like genes, CG5085 and CG6284, affect life span, we suppressed their expression using RNAi. Decreased expression of the Sir2 and Sir2-like genes in all cells caused lethality during development. Suppression of the Sir2 in neurons and ubiquitous silencing of the Sir2-like genes shortened life spans. The effects were severer at 28°C than at 25°C. These results suggest that Sir2-like genes as well as Sir2 are involved in the regulation of life span in Drosophila.
- 日本遺伝学会の論文
- 2006-10-25
著者
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松浦 悦子
お茶大・理・生物
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Ueda Ryu
Invertebrate Genetics Laboratory National Institute Of Genetics
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Ueda Ryu
Invertebrate Genetics National Institute Of Genetics
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Suda Takeshi
Department Of Bioinformatics Soka University
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Matsuura E
Ochanomizu Univ. Tokyo Jpn
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Matsuura Etsuko
Department Of Biology Ochanomizu University
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KUSAMA Sakiku
Department of Advanced Biosciences, Ochanomizu University
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NISHIHARA Shoko
Department of Bioinformatics, Soka University
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Nishihara Shoko
Department Of Bioinformatics Soka University
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Kusama Sakiku
Department Of Advanced Biosciences Ochanomizu University
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MATSUURA Etsuko
Division of Natural/Applied Sciences, Graduate School of Humanities and Sciences, Ochanomizu University
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Suda Takeshi
Department of Applied Chemistry, Faculty of Engineering, Tohoku University
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