Renal Hemodynamic Characteristics and Their Correlation with SerumAutoantibodies in Patients with Systemic Sclerosis
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the characteristics of renal hemodynamics and their correlation with serum autoantibodies in patients with systemic sclerosis (SSc). Methods : Glomerular filtration rate (GFR) and renal plasma flow (RPF) were analyzed retrospectively in three groups totaling 50 Japanese patients with SSc treated between 1982 and 1998. The filtration fraction (FF) was calculated from the values obtained for GFR and RPF (GFR/RPF). The presence of antibodies to DNA topoisomerase 1 (A-Topo) and centromere (ACA) were also examined in relation to renal hemodynamics. Results : The GFR was abnormally low in 8 (16.0%) patients, but a decreased RPF was observed in 21 (42.0%). Thus, an increased FF was frequently observed (29/50; 58.0%). A-Topo was detected in 23 patients (group A) and ACA in 10 (group B). In the remaining 17 patients (group C), however, these autoantibodies were not detected. Diffuse scleroderma or pulmonary fibrosis was more prevalent in group A than in group B. The mean GFR in group B was significantly lower than that in group C. The mean RPF in group B was significantly lower than that in the other 2 groups. Patients with an increased FF were more often found in group B than in the other 2 groups. Conclusions : A reduction in RPF disproportionate to the reduction in GFR, as demonstrated by the high FF, was observed frequently in SSc patients. Although ACA was associated with less serious cutaneous or pulmonary involvement, renal hemodynamic alterations seemed to correlate with the presence of ACA.
- 新潟大学の論文
著者
-
Arakawa M
Division Of Respiratory Medicine Niigata University Graduate School Of Medical And Dental Sciences
-
Hisashi Hasegawa
Department Of Internal Medicine (ii) Niigata Universityschool Of Medicine
-
Hasegawa Hisashi
Department Of Electronic Engineering University Of Electro-communications
-
Nakano Masaaki
Department Of Medical Technology School Of Health Sciences Faculty Of Medicine Niigata University
-
Ito S
Division Of Clinical Immunology Doctoral Program In Clinical Sciences Graduate School Of Comprehensi
-
Nakano M
Department Of Internal Medicine (ii) Niigata University School Ofmedicine
-
Masaaki NAKANO
Department of Internal Medicine (II), Niigata University School ofMedicine
-
Yuko OHUCHI
Department of Internal Medicine (II), Niigata University Schoolof Medicine
-
Yuko Ohuchi
Department Of Internal Medicine (ii) Niigata University Schoolof Medicine
-
OHUCHI Yuko
Department of Internal Medicine (II), Niigata University Schoolof Medicine
関連論文
- Analysis of Inhaled Corticosteroid Selection in Patients with Bronchial Asthma Using a Questionnaire Survey : Effects of Age, Gender, and Disease Severity
- Serum cystatin C measured by a sol particle homogeneous immunoassay can accurately detect early impairment of renal function
- Depression and anxiety associated with KDQOL in Japan according to a dialysis patient's length of time on dialysis
- Analysis of Perimenstrual Asthma Based on Questionnaire Surveys in Japan
- SAA1 gene polymorphisms and the risk of AA amyloidosis in Japanese patients with rheumatoid arthritis
- The Circadian Blood Pressure Rhythm in Non-Diabetic Hemodialysis Patients
- Determination of Optimal Blood Pressure for Patients with IgA Nephropathy Based on Renal Histology
- Adrenocorticotropic Hormone-Independent Bilateral Adrenocortical Macronodular Hyperplasia Treated with Mitotane
- A Ptient with Takayasu's Arteritis Treated with Corticosteroids Who Developed Primary Biliary Cirrhosis
- Role of Genetic Polymorphism in the SA Gene on the Blood Pressure and Prognosis of Renal Function in Patients with Immunoglobulin A Nephropathy
- Treatment of Membranoproliferative Glomerulonephritis Associated with Hepatitis C Virus Infection
- Morphometric study of glomerular basement membrane and proximal tubular basement membrane in adult thin basement membrane disease
- Disease activity and the course of wrist joint deterioration over 10 years in the patients with early rheumatoid arthritis
- Rheumatology in Japan, Germany, and Egypt : A Comparison of Medical Practices
- Improvement of Asthma Management in Actual Practice Consistent with Prevalence of Anti-inflammatory Agents : Based on Questionnaire Surveys in Niigata Prefecture, Japan from 1998 to 2002
- Drug Compliance in Patients with Bronchial Asthma : Relation among Compliance with Different Types of Antiasthmatic Drug and Association with Daily Administration Frequency
- Analysis of Drug Compliance in Adult Patients with Bronchial Asthma
- Questionnaire-based analysis of the current level of asthma control and management in Niigata Prefecture, Japan : Changes from 1998 to 2000
- Questionnaire-based characterization of bronchial asthma in the elderly : Analysis in Niigata Prefecture, Japan
- The methylguanidine-to-creatinine ratio, serum NOx concentrations, and vascular disease in nondiabetic hemodialysis patients
- Ultrastructural characteristics of diabetic nephropathy
- Clinical Features of Polymyositis/Dermatomyositis with Steroid-Resistant Interstitial Lung Disease
- Effects of omeprazole and cisapride treatment in Japanese asthmatics with reflux esophagitis
- Clinical features of Japanese patients with chronic cough induced by gastroesophageal reflux
- Patient with diffuse mesangial and endocapillary proliferative glomerulonephritis with hypocomplementemia and elecvted anti-streptolysin O treated with prednisolone, angiotensin-converting enzyme inhibitor, and angiotensin II receptor antagonist
- Questionnaire-based Analysis of the Current Status of Adult Bronchial Asthma in Niigata Prefecture : Comparison with the Asthma Guidelines
- A case of pneumatosis cystoides intestinalis in a patient with polymyositis and interstitial pneumonia
- Effectiveness of omeprazole for the treatment of upper gastrointestinal lesions in rheumatoid arthritis patients
- Systemic sclerosis in two second cousins : a case report
- Sulindac usage may not be associated with an increased incidence of renal stone formation in patients with rheumatoid arthritis
- Determination of procollagen type I carboxyterminal propeptide in Japanese patients with systemic sclerosis
- A case of Wegener's granulomatosis complicated with seropneumothorax
- Regular Exercise Improves Insulin Sensitivity, Physical Activity, and Psychosocial Status in Patients with Chronic Liver Diseases
- Flexible hinge toe implant arthroplasty for rheumatoid arthritis of the first metatarsophalangeal joint : long-term results
- Recent Advances in Basic and Clinical Studies of Glomerular BasementMembrane(GBM)
- Human parvovirus B19 infection mimicking systemic lupus erythematosus
- Mizoribine therapy in a patient with lupus nephritis : the association between mizoribine concentration and peritoneal dialysis
- Anti-neutrophil cytoplasmic autoantibodies against bactericidal/permeability-increasing protein in patients with rheumatoid arthritis and their correlation with bronchial involvement
- Acute renal failure as a complication of acquired hemophilia due to autoantibody to factor VIII
- An Analysis of Factors that Exacerbate Asthma, Based on a Japanese Questionnaire
- Expression and Intracellular Traffic of the Newly Synthesized FLAG-tagged M6a Glycoprotein
- A Severe Form of Churg-Strauss Syndrome Complicated with Acute Cardiac Failure and Rapidly Progressive Peripheral Neuropathy -A Possible Effect of Intravenous Immunoglobulin Therapy
- Selective Self-Formation of InAs Quanttun Dots on Strained InGaAs Layers by Molecular Beam Epitaxy
- Exacerbation of Atopic Dermatitis and Other Skin Diseases byConfinement in a Juvenile Classification Home
- Renal Hemodynamic Characteristics and Their Correlation with SerumAutoantibodies in Patients with Systemic Sclerosis
- Fatal Acute Pancreatitis Associated with Reactive AA Amyloidosis in Rheumatoid Arthritis with End-stage Renal Disease: A Report of Three Cases
- Pulmonary Function Analysis of Japanese Athletes : Possibly Even More Asthmatics in the Field
- FURTHER STUDY ON FLUORESCEIN ANGIOGRAPHIC FINDING IN HARADA'S DISEASE:WITH SPECIAL REFERENCE TO THE CHANGE OF OPTIC DISC
- A case of Epstein-Barr virus-related lymphadenopathy mimicking the clinical features of IgG4-related disease