Differentially Expressed Genes in the Nucleus Accumbens from Chronically Ethanol-Administered Rat

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概要

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• The isolation of differentially expressed genes in the nucleus accumbens (NA) from chronically ethanol-administered rats may help in understanding the underlying molecular mechanisms for the development and reinforcement of ethanol addiction. The differential display indicated that around 0.1-0.2% of mRNA could be considered to be affected by chronic ethanol-administration in the NA, regardless of whether ethanol directly affected gene expression in the NA or the gene alteration was secondary to changes in neuronal activity caused by ethanol. Forty-six clones were successfully reamplified, and screening by reverse Northern blot analysis resulted in the isolation of five up-regulated and three down-regulated genes. One of the up-regulated cDNAs was homologous to human TGFβ1 and its preferential expression was also observed in the cerebellum and locus coeruleus (LC). Since clone c10 displayed an extremely strong preferential expression in the ethanol-administered NA, its upstream sequence was analyzed by 5' rapid amplification of DNA ends (5'RACE) but the coding sequence has not yet been isolated, c118 showed enrichment in the ethanol-administered NA and displayed strong homology to the mouse KH domain RNA binding protein QKI-5A. The 5'RACE analysis confirmed that this clone encoded rat QKI-5A. Since QKI proteins are considered to be regulators of myelination and their absence causes dysmyelination, its up-regulation may offer protection against ethanol-induced dysmyelination. Another 12 cDNAs were registered as expression sequence tags (ESTs) or novel with their functions unknown. It is considered important, however, that to their upstream sequences including coding regions and promoter sequences are identified not only to estimate the roles of these differentially expressed genes in ethanol addiction but also to clarify whether ethanol-dependent gene-regulation can occur or not.

• 社団法人日本薬学会の論文
• 2001-04-01

著者

• Yamamoto Yuki

  Department of Dermatology, Wakayama Medical University

• ABE Shuntaro

  Department of Forensic Medicine, The Jikei University School of Medicine

• Abe Shuntaro

  金沢大学 医学系研究科衛生学

• Abe Shuntaro

  Department Of Forensic Medicine The Jikei University School Of Medicine

• Abe Shuntaro

  Department Of Forensic Medicine Jikei University School Of Medicine

• Fukunaga Tatsushige

  金沢大学 医学系研究科衛生学

• Fukunaga Tatsushige

  Tokyo Medical Examiner's Office Tokyo Metropolitan Government

• SAIJOH Kiyofumi

  Department of Hygiene, Kanazawa University School of Medicine and Graduate School of Medical Science

• Tanii Hideji

  Department of Hygiene, Kanazawa University Graduate School of Medical Science

• Leng Shuangying

  Department of Hygiene, Kanazawa University School of Medicine

• Tsutsumi Mikihiro

  Division of Gastroenterology, Department of Internal Medicine, Kanazawa Medical University

• Takase Shujiro

  Division of Gastroenterology, Department of Internal Medicine, Kanazawa Medical University

• Fukunaga Tatsushige

  Department of Forensic Medicine and Sciences, Mie University School of Medicine

• Saijoh K

  Kanazawa Univ. School Of Medicine Kanazawa Jpn

• Saijoh Kiyofumi

  金沢大学 医学系研究科衛生学

• Saijoh Kiyofumi

  Department Of Hygiene Kanazawa University School Of Medicine And Graduate School Of Medical Sciences

• Saijoh Kiyofumi

  金沢大学 衛生

• Saijoh Kiyofumi

  Department Of Environmental And Molecular Bio-informatics Kanazawa University School Of Medicine

• Tanii Hideji

  金沢大学 医学系研究科衛生学

• Tanii Hideji

  Department Of Hygiene Kanazawa University Graduate School Of Medical Science

• Tanii H

  Department Of Hygiene Kanazawa University School Of Medicine

• Tanii Hideji

  Department Of Environmental And Molecular Bio-informatics Kanazawa University School Of Medicine

• Yamamoto Yuki

  Department Of Dermatology Wakayama Medical University

• Takase Shujiro

  Division Of Gastroenterology Department Of Internal Medicine Kanazawa Medical University

• Leng Shuangying

  Department Of Hygiene Kanazawa University School Of Medicine

• Yamamoto Yuki

  Department Of Forensic Medicine And Sciences Mie University School Of Medicine

• Sumino Kimiaki

  Osaka Occupational Health Service Center Japan Industrial Safety And Health Association

• Yamamoto Yuki

  Department Of Biology Faculty Of Science Okayama University

• Yamamoto Yuki

  Department Of Basic Veterinary Science The United Graduate School Of Veterinary Sciences Gifu University

• Tanii Hisashi

  Mie Univ. Mie Jpn

• Tsutsumi Mikihiro

  Division Of Gastroenterology Department Of Internal Medicine Kanazawa Medical University

• Saijho Kiyofumi

  Department of Hygiene, Kanazawa University School of Medicine

• Fukunaga Tatsushige

  Tokyo Medical Examiner's Office, Tokyo Metropolitan Government

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