Assessment of Fertility and Reproductive Toxicity in Adult Female Mice after Long-Term Exposure to Pueraria mirifica Herb
スポンサーリンク
概要
- 論文の詳細を見る
The present study investigated the effects of long-term administration of Pueraria mirifica (PM) at non-toxic doses on the ovarian function and fertility of adult female mice based on evaluation of hematological and biochemical parameters [1]. Female mice were divided into 4 groups (36 mice/group). Groups 1-3 were orally treated with a dose of 0 (PM-0), 10 (PM-10) or 100 mg/kg BW/day PM (PM-100), and group 4 was subcutaneously injected with 200 μg/kg BW/day of synthetic estrogen diethylstilbestrol (DES). The treatment schedule was separated into treatment and post-treatment periods. The duration of each period was 8 weeks. The PM-10 mice exhibited regular estrous cycles, while the PM-100 and DES treatments induced prolonged estrous cycles. Although no changes were observed in the uterus and ovary weights of the mice after the PM-100 and DES treatments, hyperplasia of the uterine endothelium and a decrease in the number of growing ovarian follicles were detected. The changes in the ovarian histologies of the PM-100 and DES mice were related to reductions in the levels of LH and FSH, which subsequently caused a decrease in mating efficiency. Once the PM mice were able to copulate, they were capable of successfully becoming pregnant and mothering offspring. No abnormalities were observed in the external morphologies and reproductive organ weights of the 50-day-old offspring. In conclusion, our results suggest that long-term exposure to 100 mg/kg BW of PM has adverse effects on the mating efficiency and reproduction of adult female mice and that administration of 10 mg/kg BW of PM does not induce any changes in the hypothalamic-pituitary-ovarian-uterine axis.
- 日本繁殖生物学会の論文
- 2007-10-01
著者
-
Watanabe Gen
Lab. Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of Agricul
-
Taya K
Tokyo Univ. Agriculture And Technol. Tokyo
-
Taya K
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
-
WATANABE Gen
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu Uni
-
TAYA Kazuyoshi
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu Uni
-
Taya Kazuyoshi
中華人民共和国
-
Malaivijitnond Suchinda
Primate Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University
-
Watanabe Gen
中華人民共和国
-
Takano Kaoru
Laboratory Of Experimental Animal Models Division Of Bioresources National Institute Of Biomedical I
-
CHERDSHEWASART Wichai
Primate Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University
-
Cherdshewasart Wichai
Primate Research Unit Department Of Biology Faculty Of Science Chulalongkorn University
-
JAROENPORN Sukanya
Interdepartment of Physiology, Faculty of Graduate School, Chulalongkorn University
-
WATTANASIRMKIT Kingkaew
Primate Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University
-
Malaivijitnond Suchinda
Primate Research Unit Department Of Biology Faculty Of Science Chulalongkorn University
-
Watanabe Gen
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
-
Wattanasirmkit Kingkaew
Primate Research Unit Department Of Biology Faculty Of Science Chulalongkorn University
-
Jaroenporn Sukanya
Primate Research Unit Department Of Biology Faculty Of Science Chulalongkorn University
-
Taya Kazuyoshi
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
関連論文
- Changes in plasma gonadotropins, inhibin and testosterone concentrations and testicular gonadotropin receptor mRNA expression during testicular active, regressive and recrudescent phase in the captive Japanese black bear (Ursus thibetanus japonicus)
- Screening of toxicological properties of 4-methylbenzoic acid by oral administration to rats
- Formation of Primordial Follicles and Immunolocalization of PTEN, PKB and FOXO3A Proteins in the Ovaries of Fetal and Neonatal Pigs
- The Effects of Prolactin and Gonadotropin on Luteal Function and Morphology in the Cyclic Golden Hamster
- Inhibin : Regulation of reproductive function and practical use in females
- Seasonal Changes in Spermatogenesis and Immunolocalization of Cytochrome P450 17α-Hydroxylase/c17-20 Lyase and Cytochrome P450 Aromatase in the Wild Male Ground Squirrel (Citellus dauricus Brandt)
- Profiles of Circulating Steroid Hormones, Gonadotropins, Immunoreactive Inhibin and Prolactin During Pregnancy in Goats and Immunolocalization of Inhibin Subunits, Steroidogenic Enzymes and Prolactin in the Corpus Luteum and Placenta
- インヒビンα-鎖ワクチンによる初期免疫および再免疫後の牛における卵巣反応とホルモン分泌
- Protective Effect of Quercetin on the Reproductive Toxicity of 4-nitrophenol in Diesel Exhaust Particles on Male Embryonic Chickens
- Effect of NGF on the Motility and Acrosome Reaction of Golden Hamster Spermatozoa In Vitro
- 成熟雌ゴールデンハムスター(Mesocricetus auratus)の卵巣における神経成長因子(NGF)およびリセプターtrkAとp75の局在
- Effects of 3-Methyl-4-nitrophenol on the Suppression of Adrenocortical Function in Immature Male Rats(Miscellaneous)
- Expression of Nerve Growth Factor(NGF), and Its Receptors TrkA and p75 in the Reproductive Organs of the Adult Male Rats(Reproductive Biology)
- Effect of Methimazole-induced Hypothyroidism on Adrenal and Gonadal Functions in Male Japanese Quail (Coturnix japonica)
- Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats
- シャチ(Orcinus orca)の分娩前後における体温および血中プロジェステロン濃度
- Molecular analysis of rat mammary carcinogenesis : an approach from carcinogenesis research to cancer prevention
- Dose-dependent Effects of a Glucocorticoid on Prolactin Production
- Prolactin Secretion and Ovarian Function in Cycling and Non-Cycling African Female Elephants (Loxodonta africana)
- Seasonal Changes in Spermatogenesis and Immunolocalization of Inhibin/Activin Subunits in the Wild Male Ground Squirrel (Citellus dauricus Brandt)
- Long-Term Treatment with Bromocriptine Inhibits Endometrial Adenocarcinoma Development in Rats
- Secretion of Inhibin in Male Japanese Quail (Coturnix japonica) from One Week of Age to Sexual Maturity
- Secretion of Inhibin in Female Japanese Quails (Coturnix japonica) from Hatch to Sexual Maturity
- Changes in Plasma Concentrations of Inhibin A and Inhibin B Throughout Sexual Maturation in the Male Chimpanzee
- 成熟雄ラットにおける潜在精巣作出が精子運動能と精巣内分泌機能に及ぼす影響
- 雌シバヤギ生殖器における神経成長因子(NGF)およびレセプター(TrkA,p75LNGFR)の局在
- Immunolocalization of Steroidogenic Enzymes in the Fetal, Neonatal and Adult Testis of the Shiba Goat
- Immunohistochemical Localization of Inhibin α-Subunit in Two Equine Granulosa-Theca Cell Tumors
- Physiological Roles of Prolactin in the Adrenocortical Response to Acute Restraint Stress
- Direct Effects of Prolactin on Adrenal Steroidogenesis in Male Rats
- Direct Effects of Prolactin on Adrenal Steroid Release in Male Hatano High-Avoidance (HAA) Rats May be Mediated Through Janus Kinase 2 (Jak2) Activity
- Ultrasonic Vocalization Responses in Genetically High- and Low-Emotional Rats
- Effects of 3-Methyl-4-nitrophenol on the Reproductive Toxicity in Female Japanese Quail (Coturnix japonica)(Miscellaneous)
- Effects of 3-Methyl-4-Nitrophenol in Diesel Exhaust Particles on the Regulation of Reproductive Function in Immature Female Japanese Quail (Coturnix japonica)
- Age-related Changes of Reproductive Hormones in Young Meishan Boars
- Physiological Roles of Inhibin on Follicular Development during Early Pregnancy in Shiba Goats
- ウマの卵胞発育過程におけるインヒビン/アクチビンサブユニット,アロマターゼおよび3β-ヒデロキシステロイド脱水素酵素の発現
- Theriogenology: Secretion of inhibin during the estrous cycle in the female Asian elephant (Elephas maximus)
- Quercetin Protects Spermatogonial Cells from 2,4-D-Induced Oxidative Damage in Embryonic Chickens
- Changes of Cyclic AMP Levels and Phosphodiesterase Activities in the Rat Ovary
- Immunolocalization of Steroidogenic Enzymes in Equine Fetal Adrenal Glands During Mid-Late Gestation
- Immunolocalization of Inhibin/Activin Subunits in Equine Fetal Adrenal Glands during Mid Gestation
- Change in Circulating Follicle-Stimulating Hormone, Luteinizing Hormone, Immunoreactive Inhibin, Progesterone, Testosterone and Estradiol-17β in Fillies from Birth to 6 Months of Age
- Ovarian Follicular Dynamics and Hormonal Changes in Goats during Early Pregnancy
- Immunodetection of NGF, trkA, p75 and Inhibin α-Subunit in Interstitial Cells of Golden Hamsters Treated with hCG
- Expression of Nerve Growth Factor and its Receptors trkA and p75 and Inhibin α-Subunit in the Ovarian Interstitial Cells of Lactating Golden Hamsters
- Oral Administration of Kaempferia parviflora did not Disturb Male Reproduction in Rats
- Biological Significance of Follicular Fluid Discharged into the Abdominal Cavity during Ovulation in Mares
- Effects of Pantothenic Acid Supplementation on Adrenal Steroid Secretion from Male Rats(Biopharmacy)
- Immunoreactive Insulin-Like Growth Factor in Plasma during Pre- and Post-Partum Periods of Thoroughbred Mares from which the Newborn were Removed : its Pattern, Physiological Function and Relation to Other Hormones
- 輸送ストレスが雌馬のLHおよびFSH分泌に及ぼす影響について;予備的検討
- 21WA-04-1 Effects on reproductive tract of male Donryu rats by neonatal exposure of p-tert octylphenol
- 21WA-03-5 Persistent effects on the reproductive tract in female rats by neonatal exposure of p-tert-octylphenol.
- Diesel Exhaust Particle Toxicity on Spermatogenesis in the Mouse is Aryl Hydrocarbon Receptor Dependent
- EFFECT OF HYPERPROLACTINEMIA INDUCED BY PITUITARY GRAFTS OR CASTRATION ON PORPHYRIN CONTENT OF THE MOUSE HARDERIAN GLAND
- Induction of Estrus and Promotion of Fertility by Prostaglandin F_2a Administration in Mares
- A Surge-Like Increase in Luteinizing Hormone Preceding Musth in a Captive Bull African Elephant (Loxodonta africana)
- モルモットにおけるインヒビンαサブユニットに対する受動免疫後のイムノグロブリンGとインヒビンαサブユニットの卵巣内局在
- Effect of a Single Injection of Human Chorionic Gonadotropin (hCG) on Testicular Hormones and Gonadotropins in the Thoroughbred Stallion
- Immunolocalization of Inhibin/Activin Subunits and Steroidogenic Enzymes in Equine Neonatal Ovaries
- A Thoroughbred Showing Development Disorder in the Pudendal Cleavage due to Chromosomal Mosaicism
- 2A-02 Effects on Spermatogenesis of Reduced Testosterone Secretion by Leuprorelin Acetate in Rats
- Effects of Hypothyroidism on Gonadal Function after Transition of Short Day Photoperiod in Male Golden Hamsters (Mesocricetus auratus)
- Expression of Nerve Growth Factor (NGF), and Its Receptors trkA and p75 in Ovaries of the Cyclic Golden Hamster (Mesocricetus auratus) and the Regulation of Their Production by Luteinizing Hormone
- Age-Related Changes in the Serum Levels of Inhibin, FSH, LH and Testosterone in Holstein Bulls
- Effects of Vertically Transferred 3,3',4,4',5-Pentachlorobiphenyl on Gene Expression in the Ovaries of Immature Sprague-Dawley Rats
- Different Effects of Pueraria mirifica, a Herb Containing Phytoestrogens, on LH and FSH Secretion in Gonadectomized Female and Male Rats
- Ovarian Localization of Immunoglobulin G and Inhibin α-Subunit in Guinea Pigs after Passive Immunization against the Inhibin α-Subunit
- Immunolocalization of Nerve Growth Factor (NGF) and Its Receptors (TrkA and p75LNGFR) in the Reproductive Organs of Shiba Goats
- Effects of Pantothenic Acid on Testicular Function in Male Rats
- Assessment of Urinary Gonadotropin and Steroid Hormone Profiles of Female Cynomolgus Monkeys after Treatment with Pueraria mirifica
- ウシXY雌におけるeCG、hCG、GnRH-A投与前後の血中FSH、LH、inhibin、E2、P、T濃度の変化
- Ovarian Follicular Dynamics and Hormonal Changes in Goats during Early Pregnancy
- Quercetin Attenuates Oxidative Damage Induced by Treatment of Embryonic Chicken Spermatogonial Cells with 4-Nitro-3-phenylphenol in Diesel Exhaust Particles
- Endocrine Disruptive Effect of 3-Methyl-4-nitrophenol Isolated from Diesel Exhaust Particles in Hershberger Assay Using Castrated Immature Rats
- Alleviative Effects of Quercetin and Onion on Male Reproductive Toxicity Induced by Diesel Exhaust Particles
- Cyclic Changes in Serum Follicle-Stimulating Hormone, Luteinizing Hormone and Inhibin During the Guinea Pig Estrous Cycle
- Changes in FSH, LH and Prolactin Secretion During Estrous Cycle in Rats
- Assessment of Fertility and Reproductive Toxicity in Adult Female Mice after Long-Term Exposure to Pueraria mirifica Herb
- The influence of Pueraria mirifica herb containing phytoestrogens on the urinary gonadotropin and estradiol levels in aged menopausal monkeys
- Cellular Localization of Inhibin α-subunit, PKB/Akt and FoxO3a Proteins in the Ovaries of Minipigs
- Localization of Ovarian Inhibin/Activin Subunits in Follicular Dominance during the Estrous Cycle of Guinea Pigs : Reproductive Biology
- Effects of Diesel Exhaust Particles on the Male Reproductive System in Strains of Mice with Different Aryl Hydrocarbon Receptor Responsiveness
- Post-Natal Dynamic Changes in Circulating Follicle-Stimulating Hormone, Luteinizing Hormone, Immunoreactive Inhibin, Progesterone, Testosterone and Estradiol-17β in Thoroughbred Colts until 6 Months of Age
- Estrogenic Effect of Pueraria mirifica, a Thai Medicinal plant, on hormone modulation in menopausal monkeys
- Effect of Prostaglandin F2α upon Ovulation and LH, FSH and Prolactin Secretion in Chlorpromazine Blocked Rats
- A New More Potent Analogue of LH-RH : [Des-Gly-NH210, Pro-ethylamide9]-LH-RH
- Circadian Rhythms in Serum LH, FSH and Prolactin Levels in Adult Male Rats
- Effect of Daily Treatment with Thai Herb, Kaempferia parviflora, in Hershberger Assay Using Castrated Immature Rats
- Annual Changes in Day-length, Temperature, and Circulating Reproductive Hormones in Thoroughbred Stallions and Geldings
- Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats
- Adult onset cardiac dilatation in a transgenic mouse line with Galβ1,3GalNAc α2,3-sialyltransferase II (ST3Gal-II) transgenes: a new model for dilated cardiomyopathy
- シャトルボックス条件回避行動時におけるHatano高回避系および低回避系ラットの内分泌学的系統差
- Seasonal Changes in Immunoreactivity of Activin Signaling Component Proteins in Wild Ground Squirrel Testes
- Follicular Turnover and Hormonal Association in Postpartum Goats During Early and Late Lactation
- The Secretory Pattern and Source of Immunoreactive Prolactin in Pregnant African (Loxodonta africana) and Asian (Elephas maximus) Elephants
- Endocrine Mechanisms Responsible for Different Follicular Development During the Estrous Cycle in Hatano High- and Low-avoidance Rats
- Effects of pantothenic acid supplement on secretion of steroids by the adrenal cortex in female rats
- Effects of exogenous 17β-estradiol on follicular development in the neonatal and immature mouse in vivo
- Seasonal Changes in Morphology and Immunoreactivity of PDGF-A and its Receptor PDGFR-α in the Epididymis of Wild Ground Squirrels (Citellus dauricus Brandt)