Effect of Methimazole-induced Hypothyroidism on Adrenal and Gonadal Functions in Male Japanese Quail (Coturnix japonica)
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概要
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To investigate the effect of hypothyroidism on gonadal and adrenal functions in male Japanese quail, hypothyroidism was induced in male adult Japanese quail by daily administration of 2-Mercapto-1-methylimidazole (methimazole) in their drinking water. Four weeks after methimazole treatment, the Japanese quail were scarificed, and the plasma concentrations of free triiodothyronine (FT3), free thyroxine (FT4), total T3 (TT3), total T4 (TT4), corticosterone, testosterone, LH and immunoreactive (ir) inhibins were measured by radioimmunoassy, the testes and adrenal glands were removed and weighed and the thyroid glands and testes were fixed in 4% paraformaldehyde for histological observation. The results showed that the hypothyroidism induced by methimazole caused a significant decrease in body and testes weight; the plasma levels of FT3, FT4 and TT4 significantly decreased, and the hypothyroid quail possessed a greater number of small follicles and more follicular epithelial cells in the thyroid gland. In addition, hypothyroidism resulted in a significant decrease in the plasma concentrations of corticosterone, LH, testosterone and ir-inhibin. Furthermore, no spermatogenesis was found in the seminiferous tubules of the methimazole treatment groups. These results clearly demonstrate that hypothyroidism caused both gonadal and adrenal disturbances in the adult male Japanese quail.
- 2007-12-01
著者
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TANEDA Shinji
Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for
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WATANABE Gen
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
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SUZUKI Akira
Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for
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TAYA Kazuyoshi
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
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Watanabe Gen
Lab. Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of Agricul
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Watanabe Gen
岐阜大学 連合獣医学研究科基礎獣医学
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Taneda Shinji
Ecological Effect Research Team Dioxin And Environmental Endocrine Disrupter Research Project Nation
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Taneda Shinji
岐阜大学 連合獣医学研究科基礎獣医学連合講座
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Taneda Shinji
Environmental Nanotoxicology Section Res. Center For Environmental Risk National Inst. For Environme
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Taneda Shinji
中華人民共和国
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Taya Kazuyoshi
岐阜大学 連合獣医学研究科基礎獣医学
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Taya K
Tokyo Univ. Agriculture And Technol. Tokyo
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Taya Kazuyoshi
日本中央競馬会競走馬総合研究所
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Taya K
Dep. Of Basic Veterinary Sci. The United Graduate School Of Veterinary Sciences Gifu Univ.
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WENG Qiang
College of Biological Science and Technology, Beijing Forestry University
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Taya Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Taya Kazuyoshi
中華人民共和国
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Taya Kazuyoshi
Laboratory Of Veterinary Physiology Tokyo University Of Agriculture And Technology
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Taya K
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Tokyo University Of Agricultur
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Weng Qiang
College Of Biological Science And Technology Beijing Forestry University
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Suzuki Akira
Environmental Nanotoxicology Section Research Center For Environmental Risk National Institute For E
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SAITA Erina
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
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TAKAHASHI Shinji
Ecological Effect Research Team, Dioxin and Environmental Endocrine Disrupter Research Project, Nati
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SEDQYAR Manila
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
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Watanabe Gen
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Sakushima A
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Sakushima A
Central Institute Of Isotope Science Graduate School Of Medicine Hokkaido University
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Taya Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Tokyo University Of Agricultur
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Watanabe Gen
中華人民共和国
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Taya Kazuyoshi
東京農工大学 農学部獣医学科獣医生理学
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斉田 栄里奈
東京農工大学農学部・獣医学科・家畜生理学教室
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Saita E
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Sedqyar Manila
Department Of Basic Veterinary Science The United Graduate School Of Veterinary Sciences Gifu Univer
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Takano Kaoru
Laboratory Of Experimental Animal Models Division Of Bioresources National Institute Of Biomedical I
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STRAWN EY
Medical College of Wisconsin
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Takimoto Kazuhiro
Department Of Veterinary Science National Institute Of Health
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Tago Kazumi
Hatano Research Institute Food And Drug Safety Center
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Weng Qiang
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Watanabe Gen
Laboratories Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of
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Takahashi Shinji
Ecological Effect Research Team Dioxin And Environmental Endocrine Disrupter Research Project National Institute For Environmental Studies
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Suzuki A
Environmental Newtoxicology Section Research Center For Environmental Risk National Institute For Environmental Studies
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