Roles of the Basal Level of LH and FSH in the Regulation of Follicular Development during Pseudopregnancy in the Rat
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概要
- 論文の詳細を見る
Present study was conducted to investigate roles of the basal level of FSH and LH in the follicular maturation and maintenance during pseudopregnancy of the rat. Antiserum against luteinizing hormone releasing hormone (LHRH-AS) or charcoal-treated porcine follicular fluid (PFF; a crude inhibin preparation) was given to individual animals on day 5 of pseudopregnancy. Plasma LH and inhibin decreased after treatment with LHRH-AS. Contrarily, plasma FSH increased after LHRH-AS injection. The number of follicles capable of ovulating in response to human chorionic gonadotropin (hCG) in animals given LHRH-AS declined gradually, reached a nedir at 24 h after the treatment, and then returned to control levels during the subsequent 24 h. On the other hand, plasma FSH levels in rats given three injections of 0.5 ml PFF at 6-h intervals, compared to those in control animals, remained significantly lower at nearly all time points during the first 24 h after the initial PFF injection, and thereafter the hormone levels temporarily increased, being significantly elevated above the control value at 30 and 42 h after the initial PFF injection. Only in the rats given intraperitoneal injections of 0.5 ml PFF, compared to the control animals, plasma LH concentrations remained significantly lower at 9 h after the initial PFF injection and those values were significantly higher at 36 h after the initial treatment. The number of follicles capable of ovulating in response to hCG decreased in PFF-treated animals in a dose-dependent-manner. The follicular development in animals given injection of 0.5 ml PFF were virtually or completely inhibited from 12 to 36 h after the initial injection of PFF. Present results clearly indicate that the basal secretion of both LH and FSH are essential for follicular development and maintenance during pseudopregnancy of the rat. These results also suggest that inhibin is a primary factor to suppress FSH secretion in the pseudopregnant rat.
- 日本繁殖生物学会の論文
著者
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WATANABE Gen
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
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TAYA Kazuyoshi
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
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Kishi Hisashi
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-ch
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Kishi Hisashi
Center For International Environmental Health Dokkyo Medical University
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Kondo M
Tokyo Univ. Agriculture And Technol. Tokyo Jpn
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Kondoh Masahiro
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 18
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Nagamine Natsuko
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 18
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SHI Fagxiong
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 18
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