Involvement of Ovarian Inhibin and Steroid Hormones in the Regulation of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) Secretion during Pseudopregnancy in the Rat
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概要
- 論文の詳細を見る
Roles of ovarian inhibin and steroids in the regulation of basal secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) were examined during pseudopregnancy in the rat. Bilateral or unilateral ovariectomy performed on either day 5 or 10 of pseudopregnancy (day 0; the day after copulation with a vasectomized male) produced a significant increase in plasma FSH concentrations within 6 h. During the subsequent 18 h, plasma FSH concentrations in unilaterally ovariectomized rats declined to a baseline level, and the gonadotropin concentrations in bilaterally ovariectomized rats remained significantly elevated above the value measured in sham-operated (control) animals. Plasma LH concentrations on either day 5 or 10 were not significantly altered by bilateral or unilateral ovariectomy. Plasma inhibin concentrations on both days 5 and 10 declined to an undetectable level within 6 h after bilateral ovariectomy. In unilateral ovariectomized rats, compared to control animals, a significant decrease in plasma inhibin concentrations was evident at 6 and 12 h, but not at 24 h, after the operation on both days 5 and 10. On day 5, administration of charcoal-treated porcine follicular fluid (an inhibin preparation) eliminated the increase in plasma FSH concentrations produced by bilateral ovariectomy within 24 h without affecting plasma LH concentrations. Plasma FSH and LH concentrations in rats bilaterally ovariectomized on day 5 were not significantly altered by administration of estradiol or progesterone alone, whereas both gonadotropin concentrations in these animals were slightly but significantly suppressed as late as 24 h after combined administration of estradiol and progesterone. In addition, in intact pseudopregnant rats, administration of antiserum against inhibin resulted in a marked increase in plasma FSH concentrations accompanied by a small but significant increase in plasma LH on day 5. These results collectively suggest that ovarian inhibin is a major regulator of FSH secretion during pseudopregnancy in the rat.
- 日本繁殖生物学会の論文
- 1997-08-01
著者
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WATANABE Gen
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
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TAYA Kazuyoshi
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
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Arai Koji
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Tokyo University Of Agricultur
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KISHI Hisashi
Center for International Environmental Health, Dokkyo Medical University
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Kishi Hisashi
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-ch
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Kondo Masahiro
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-ch
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Taya Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Konishi Masato
Embryo Transfer Center Zen-noh
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Kishi Hisashi
Center For International Environmental Health Dokkyo Medical University
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Kondo M
Tokyo Univ. Agriculture And Technol. Tokyo Jpn
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Kondo Masahiro
ノバルティスアニマルヘルス
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Watanabe Gen
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Yamanouchi K
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Araki Kodachi
Laboratory Of Veterinary Physiology Faculty Of Agriculture Tokyo University Of Agriculture And Techn
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Kishi Hisashi
Laboratory Of International Environmental Health Dokkyo Medical University School Of Medicine
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Konishi Masato
Laboratory Of Veterinary Physiology Tokyo University Of Agriculture And Technology
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Araki Kodachi
Laboratory Of Veterinary Physiology Faculty Of Agriculture Tokyo University Of Agriculture And Techn
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Watanabe Gen
Laboratories Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of
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KONDO Masahiro
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
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