Changes of Cyclic AMP Levels and Phosphodiesterase Activities in the Rat Ovary
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概要
- 論文の詳細を見る
Cyclic AMP (cAMP) is a second messenger that plays a critical role in follicular recruitment, development, and luteinization in the mammalian ovary. The cellular level of cAMP is largely dependent on the activity of phosphodiesterase (PDE), which degrades cAMP into 5-AMP. The present study was conducted to investigate the level of cAMP and the activity of cAMP-PDE in postnatal rats; immature rats during gonadotropin-primed follicular development, ovulation, and luteinization; adult rats during normal estrous cycling; and aged rats that spontaneously developed persistent estrous (PE) by radioimmunoassay (RIA). All four rat models were confirmed by histological examination of one ovary and assayed using the other ovary by RIA. In the postnatal rats, the ovarian cAMP level was high on day 10 after birth, while ovarian cAMP-PDE activity was highest at 21 days of age. In the immature female rats, both the ovarian cAMP level and cAMP-PDE activity increased remarkably after treatment with equine chorionic gonadotropin (eCG), increased continuously 24 h after injection of human chorionic gonadotropin (hCG) for induction of ovulation and luteinization, and then declined significantly. In the adult rats during the normal estrous cycle, the ovarian cAMP levels were low on the day of estrus, and there were no significant changes in ovarian cAMP-PDE activity throughout the estrous cycle. In the PE rats, the ovarian cAMP levels were similar to those of the adult rats on the day of estrus but were lower than those on the other days of the estrous cycle; ovarian cAMP-PDE activity was lower than that in the adult rats on any day of the estrous cycle. Together, these findings indicate that the ovarian cAMP level and cAMP-PDE activity were regulated in a stage-dependent manner during ovarian follicular development, atresia, and luteinization and providing evidence that cAMP and cAMP-specific PDEs are involved in these physiological processes.
- 日本繁殖生物学会の論文
- 2007-08-01
著者
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WATANABE Gen
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
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TAYA Kazuyoshi
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
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Watanabe Gen
Lab. Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of Agricul
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Watanabe Gen
岐阜大学 連合獣医学研究科基礎獣医学
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Taya Kazuyoshi
岐阜大学 連合獣医学研究科基礎獣医学
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Taya Kazuyoshi
日本中央競馬会競走馬総合研究所
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Taya K
Dep. Of Basic Veterinary Sci. The United Graduate School Of Veterinary Sciences Gifu Univ.
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Taya Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Taya Kazuyoshi
中華人民共和国
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Taya Kazuyoshi
Laboratory Of Veterinary Physiology Tokyo University Of Agriculture And Technology
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Taya K
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Tokyo University Of Agricultur
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Lu Li-zhi
Institute Of Animal Sciences And Veterinary Medicine Zhejiang Academy Of Agricultural Sciences
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Jiang Yong-qing
Institute Of Animal Sciences And Veterinary Medicine Zhejiang Academy Of Agricultural Sciences
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Watanabe Gen
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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SHI Fangxiong
Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural Un
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WANG Zhengchao
Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural Un
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WANG Hao
Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural Un
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Wang Zhengchao
Laboratory Of Animal Reproduction College Of Animal Science And Technology Nanjing Agricultural Univ
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Taya Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Tokyo University Of Agricultur
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Watanabe Gen
中華人民共和国
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Shi F
Laboratory Of Animal Reproduction College Of Animal Science And Technology Nanjing Agricultural Univ
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Shi Fangxiong
Laboratory Of Animal Reproduction College Of Animal Science And Technology Nanjing Agricultural Univ
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Takimoto Kazuhiro
Department Of Veterinary Science National Institute Of Health
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Shi Fangxiong
Laboratory Of Animal Reproduction College Of Animal Science And Technology Nanjing Agricultural Univ
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Wang Hao
Laboratory Of Animal Reproduction College Of Animal Science And Technology Nanjing Agricultural Univ
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Tago Kazumi
Hatano Research Institute Food And Drug Safety Center
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Watanabe Gen
Laboratories Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of
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