外因性卵胞刺激ホルモン(FSH)投与による過剰排卵誘起におけるインヒビン能動免疫の効果
スポンサーリンク
概要
- 論文の詳細を見る
The effect of active immunization against inhibin on the response to superovulatory treatment by porcine FSH (pFSH) was investigated in cattle. Japanese black cows were sc injected with 1 mg of porcine inhibin α-subunit fragment (1-26) conjugated with rabbit serum albumin (inhibin-immunized group; n=14) or rabbit serum albumin alone (control group; n=12) in Freunds complete adjuvant. Booster injections (half the amount of the primary injection) were given 35 and 70 days after the primary injection. All cows were superovulated three times with pFSH. Three days after each injection of the antigen, a progesterone-releasing intravaginal device (CIDR-B) was inserted vaginally into all animals and left in place for 10 days. Forty-eight hours before CIDR-B removal, all animals were sc injected with 30 mg pFSH dissolved in 40% polyvinylpyrrolidone, and im injected with 750 μg of PGF2α at CIDR-B removal. Cows were artificially inseminated twice during estrus, and ova or embryos were collected 7 or 8 days after estrus. The number of corpora lutea, the number of ova or embryos and the number of transferable embryos in inhibin-immunized cows (12.1 ± 1.2, 11.1 ± 1.3 and 6.2 ± 1.0, respectively) were significantly greater than those in the controls (8.2 ± 1.0, 5.7 ± 1.1 and 3.1 ± 0.7, respectively). These results indicate that active immunization against inhibin enhanced ovarian response to the usual superovulatory treatment in cattle. Therefore, immunization against inhibin may be a useful approach for improving the response to superovulation in cattle.
- 日本繁殖生物学会の論文
著者
-
WATANABE Gen
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
-
TAYA Kazuyoshi
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
-
岸 久司
Department of Animal Reproduction, National Institute of Agrobiological Resource
-
MEDAN Mohamed
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
-
Taya Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
-
武富 敏郎
Embryo Transfer Center, ZEN-NOH
-
AOYAGI Yoshito
Embryo Transfer Center, ZEN-NOH
-
KONISHI Masato
Embryo Transfer Center, ZEN-NOH
-
ITOH Takako
Embryo Transfer Center, ZEN-NOH
-
YAZAWA Shigeto
Embryo Transfer Center, ZEN-NOH
-
Konishi Masato
Embryo Transfer Center Zen-noh
-
岸 久司
(独)畜産草地研究所・家畜育種繁殖部
-
Watanabe Gen
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
-
KISHI Hisashi
Department of Animal Reproduction, National Institute of Agrobiological Resource
-
TAKEDOMI Toshiro
Embryo Transfer Center, ZEN-NOH
-
Yazawa Shigeto
Embryo Transfer Center Zen-noh
-
Itoh Takako
Embryo Transfer Center Zen-noh
-
Medan Mohamed
Laboratory Of Veterinary Physiology Tokyo University Of Agriculture And Technology
-
Watanabe Gen
Laboratories Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of
-
AOYAGI Yoshito
Embryo Transfer Center
-
KONISHI Masato
Embryo Transfer Center
-
YAZAWA Shigeto
Embryo Transfer Center
-
TAKEDOMI Toshiro
Embryo Transfer Center
関連論文
- Effects of Acute Restraint Stress on Sperm Motility and Secretion of Pituitary, Adrenocortical, and Gonadal Hormones in Adult Male Rats
- Ovarian Follicular Dynamics and Hormonal Changes in Goats during Early Pregnancy
- Quercetin Attenuates Oxidative Damage Induced by Treatment of Embryonic Chicken Spermatogonial Cells with 4-Nitro-3-phenylphenol in Diesel Exhaust Particles
- Protective Effect of Quercetin on the Reproductive Toxicity of 4-nitrophenol in Diesel Exhaust Particles on Male Embryonic Chickens
- ニホンザル(Macaca fuscata fuscata)の妊娠中および泌乳期初期の血中リラキシン濃度の変化
- ニホンザル妊娠後期におけるプロスタグランジンE2の子宮頸管成熟に及ぼす影響と血中リラキシン、黄体形成ホルモン(LH)、エストラジオール-17βおよびプロゲステロン濃度の変化
- The Effects of Prolactin and Gonadotropin on Luteal Function and Morphology in the Cyclic Golden Hamster
- Ontogeny of testicular inhibin and activin in ducks : An immunocytochemical analysis
- Changes in Expression of Inhibin Subunits in the Cyclic Golden Hamster (Mesocricetus auratus) and the Regulation of Inhibin α Subunit Production by Luteinizing Hormone
- Changes in Inhibin Secretion during Development of the Female Duck Embryo(Reproductive Biology)
- Inhibition of Ovarian Follicular Development Associated with a Decrease in Luteinizing Hormone Levels During the Estrous Cycle of the Rat
- Involvement of Ovarian Inhibin and Steroid Hormones in the Regulation of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) Secretion during Pseudopregnancy in the Rat
- Effects of Passive Immunization Against Estradiol on LH and FSH in the Diestrous Female Rat
- Profiles of Circulating Steroid Hormones, Gonadotropins, Immunoreactive Inhibin and Prolactin During Pregnancy in Goats and Immunolocalization of Inhibin Subunits, Steroidogenic Enzymes and Prolactin in the Corpus Luteum and Placenta
- Protective Effect of Quercetin on the Reproductive Toxicity of 4-nitrophenol in Diesel Exhaust Particles on Male Embryonic Chickens
- 外因性卵胞刺激ホルモン(FSH)投与による過剰排卵誘起におけるインヒビン能動免疫の効果
- Effect of NGF on the Motility and Acrosome Reaction of Golden Hamster Spermatozoa In Vitro
- ニホンザル卵巣における神経成長因子(NGF)、およびレセプター(trkA、p75LNGFR)の局在
- Effects of 3-Methyl-4-nitrophenol on the Suppression of Adrenocortical Function in Immature Male Rats(Miscellaneous)
- Effect of Methimazole-induced Hypothyroidism on Adrenal and Gonadal Functions in Male Japanese Quail (Coturnix japonica)
- 発情周期中および妊娠中のヤギ卵巣におけるインヒビンα,βA,βB鎖,3β-hydroxysteroid dehydrogenaseおよびcytochrome P450 aromataseの局在
- Molecular analysis of rat mammary carcinogenesis : an approach from carcinogenesis research to cancer prevention
- 短時間照明条件下で精巣機能を変化させたゴールデンハムスター精巣におけるインヒビン分泌
- 妊娠ゴールデンハムスターの卵胞発育における基底レベルのLHの役割
- 雄ゴールデンハムスターの成長過程における精巣機能とインヒビン分泌
- The Effects of Prolactin and Gonadotropin on Luteal Function and Morphology in the Cyclic Hamster
- Follicular Ability to Secrete Estradiol and Apoptotic DNA Fragmentation in a Hamster Model of Induced Follicular Atresia
- Changes in Plasma Concentrations of Immunoreactive Inhibin and Estradiol-17β in the Golden Hamster Superovulated by Equine Chorionic Gonadotropin (eCG)
- Low Plasma Estradiol is Required for the Expression of Daily Increase in Plasma Gonadotropins in the Lactating Golden Hamster (Mesocricetus auratus)
- Roles of the Basal Level of LH and FSH in the Regulation of Follicular Development during Pseudopregnancy in the Rat
- Changes in Plasma Concentrations of Immunoreactive Inhibin, Estradiol and FSH Associated with Follicular Waves during the Estrous Cycle of the Cow
- Dose-dependent Effects of a Glucocorticoid on Prolactin Production
- Seasonal Changes in Spermatogenesis and Immunolocalization of Inhibin/Activin Subunits in the Wild Male Ground Squirrel (Citellus dauricus Brandt)
- 繁殖期における雌ニホンザル正常月経周期中のインヒビンAとインヒビンB分泌
- アヒルの排卵周期における血中インヒビン、性腺刺激ホルモンおよびステロイドホルモン濃度
- Effects of Third Ventricle Injention of Norepinephrine Analogue on LH Secretion of the Non-Laying SIJI Goose
- Inhibin B is the major form of inhibin secreted from testes in male Japanese macaques (Macaca fuscata)
- シバヤギの黄体および胎盤におけるステロイドホルモン合成酵素の局在
- シバヤギの胎子、新生子および成獣の精巣におけるインヒビンサブユニットの局在
- インヒビン受動免疫法によるミニシバヤギの排卵数増加
- インヒビン中和法による幼若ラットの過排卵誘起
- Expression of Inhibin/Activin Subunits in the Ovaries of Fetal and Neonatal Mice
- Seasonal Changes in Immunolocalization of Inhibin/Activin Subunits and Testicular Activity in Wild Male Raccoon Dogs (Nyctereutes procyonoides)
- Immunization of Goats against Inhibin Increased Follicular Development and Ovulation Rate
- Immunolocalization of Steroidogenic Enzymes in the Fetal, Neonatal and Adult Testis of the Shiba Goat
- Immunohistochemical Localization of Inhibin α-Subunit in Two Equine Granulosa-Theca Cell Tumors
- 超音波画像診断によるヤギの繁殖成績向上のための早期妊娠診断
- Busulfan胎生期曝露による第一次卵胞減少はDonryuラットの子宮発癌を促進する
- 雌ウマの分娩前後における血中インヒビン濃度測定の有用性
- Ultrasonic Vocalization Responses in Genetically High- and Low-Emotional Rats
- Endocrine Disruptive Effect of 3-Methyl-4-nitrophenol Isolated from Diesel Exhaust Particles in Hershberger Assay Using Castrated Immature Rats
- Effects of 3-Methyl-4-nitrophenol on the Reproductive Toxicity in Female Japanese Quail (Coturnix japonica)(Miscellaneous)
- ホルスタイン種雄牛の加齢にともなう血中ホルモン濃度の変化
- Age-related Changes of Reproductive Hormones in Young Meishan Boars
- Physiological Roles of Inhibin on Follicular Development during Early Pregnancy in Shiba Goats
- ウマの卵胞発育過程におけるインヒビン/アクチビンサブユニット,アロマターゼおよび3β-ヒデロキシステロイド脱水素酵素の発現
- Changes of Cyclic AMP Levels and Phosphodiesterase Activities in the Rat Ovary
- 老齢カニクイザルに対するPueraria mirifica(植物エストロゲン)の長期投与が血中上皮小体ホルモンおよびカルシウムレベルに及ぼす影響
- Immunolocalization of Steroidogenic Enzymes in Equine Fetal Adrenal Glands During Mid-Late Gestation
- Immunolocalization of Inhibin/Activin Subunits in Equine Fetal Adrenal Glands during Mid Gestation
- Ovarian Follicular Dynamics and Hormonal Changes in Goats during Early Pregnancy
- Immunodetection of NGF, trkA, p75 and Inhibin α-Subunit in Interstitial Cells of Golden Hamsters Treated with hCG
- Expression of Nerve Growth Factor and its Receptors trkA and p75 and Inhibin α-Subunit in the Ovarian Interstitial Cells of Lactating Golden Hamsters
- Oral Administration of Kaempferia parviflora did not Disturb Male Reproduction in Rats
- Mitosis and inhibin production in ovarian follicular granulosa cells during the estrous cycle of rats
- Role of periovulatory FSH surges on follicular development during the estrous cycle of rats
- 輸送ストレスが雌馬のLHおよびFSH分泌に及ぼす影響について;予備的検討
- Uterine Adenocarcinoma in N-Ethyl-N'-nitro-N-nitrosoguanidine-treated Rats with High-dose Exposure to p-tert-Octylphenol during Adulthood
- Immunopotentiator from Pantoea agglomerans 1 (IP-PA1)は経口投与によりメラノーマ担癌マウスの生存を改善する
- EFFECT OF HYPERPROLACTINEMIA INDUCED BY PITUITARY GRAFTS OR CASTRATION ON PORPHYRIN CONTENT OF THE MOUSE HARDERIAN GLAND
- Cyclic Changes in Serum Follicle-Stimulating Hormone, Luteinizing Hormone and Inhibin During the Guinea Pig Estrous Cycle
- Induction of Estrus and Promotion of Fertility by Prostaglandin F_2a Administration in Mares
- Effect of a Single Injection of Human Chorionic Gonadotropin (hCG) on Testicular Hormones and Gonadotropins in the Thoroughbred Stallion
- Active Immunization against Inhibin Improves Superovulatory Response to Exogenous FSH in Cattle
- Age-Related Changes in the Serum Levels of Inhibin, FSH, LH and Testosterone in Holstein Bulls
- ウシXY雌におけるeCG、hCG、GnRH-A投与前後の血中FSH、LH、inhibin、E2、P、T濃度の変化
- Long-Term Treatment Effects of Pueraria mirifica Phytoestrogens on Parathyroid Hormone and Calcium Levels in Aged Menopausal Cynomolgus Monkeys
- TCDD Increases Inhibin A Production by Human Luteinized Granulosa Cells In Vitro
- Effects of Vertically Transferred 3,3',4,4',5-Pentachlorobiphenyl on Gene Expression in the Ovaries of Immature Sprague-Dawley Rats
- Different Effects of Pueraria mirifica, a Herb Containing Phytoestrogens, on LH and FSH Secretion in Gonadectomized Female and Male Rats
- Reduction of Primordial Follicles Caused by Maternal Treatment with Busulfan Promotes Endometrial Adenocarcinoma Development in Donryu Rats
- Inhibin Pro-αC as the Marker of Testicular Function in the Stallion
- シバヤギの胎子、新生子および成獣の精巣におけるインヒビンサブユニットの局在
- ヤギの発情周期中における卵胞発育と血中ホルモン濃度の変化
- Plasma Concentrations of Immunoreactive (ir)-Inhibin, Gonadotropins and Steroid Hormones during the Ovulatory Cycle of the Duck
- Immunolocalization of Steroidogenic Enzymes P450scc, 3βHSD, P450c17, and P450arom in Gottingen Miniature Pig Testes
- Immunolocalization of Steroidogenic Enzymes in the Corpus Luteum and Placenta of the Japanese Shiba Goat
- インヒビン受動免疫法によるミニシバヤギの排卵数増加
- 超音波画像診断によるヤギの繁殖成績向上のための早期妊娠診断
- Assessment of Urinary Gonadotropin and Steroid Hormone Profiles of Female Cynomolgus Monkeys after Treatment with Pueraria mirifica
- Assessment of Urinary Gonadotropin and Steroid Hormone Profiles of Female Cynomolgus Monkeys after Treatment with Pueraria mirifica
- Ovarian Follicular Dynamics and Hormonal Changes in Goats during Early Pregnancy
- Quercetin Attenuates Oxidative Damage Induced by Treatment of Embryonic Chicken Spermatogonial Cells with 4-Nitro-3-phenylphenol in Diesel Exhaust Particles
- Endocrine Disruptive Effect of 3-Methyl-4-nitrophenol Isolated from Diesel Exhaust Particles in Hershberger Assay Using Castrated Immature Rats
- Maternal Isobutyl-Paraben Exposure decreases the Plasma Corticosterone Level in Dams and Sensitivity to Estrogen in Female Offspring Rats
- Induction of Superovulation by Immunoneutralization of Endogenous Inhibin in Immature Rats
- Cyclic Changes in Serum Follicle-Stimulating Hormone, Luteinizing Hormone and Inhibin During the Guinea Pig Estrous Cycle
- Roles of the Basal Level of LH and FSH in the Regulation of Follicular Development during Pseudopregnancy in the Rat
- Involvement of Ovarian Inhibin and Steroid Hormones in the Regulation of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) Secretion during Pseudopregnancy in the Rat
- Effects of Passive Immunization Against Estradiol on LH and FSH in the Diestrous Female Rat