Profiles of Circulating Steroid Hormones, Gonadotropins, Immunoreactive Inhibin and Prolactin During Pregnancy in Goats and Immunolocalization of Inhibin Subunits, Steroidogenic Enzymes and Prolactin in the Corpus Luteum and Placenta
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概要
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The current study was performed to follow up the circulating hormonal changes and to correlate the findings with the physiological activity of the corpus luteum (CL) and placenta during pregnancy in goats. Blood samples were collected weekly from five goats during pregnancy for measuring steroid and protein hormones. A gradual increase was observed in immunoreactive (ir-) inhibin, with maximal levels at the 17th week. The plasma concentrations of estradiol and prolactin (PRL) showed nearly similar patterns during pregnancy, where they declined to basal levels during the first 4 weeks post-breeding and then increased significantly, with the maximal concentration during late pregnancy. The plasma FSH and LH concentrations were maintained at basal levels throughout the gestation period. The plasma progesterone concentration abruptly increased in the first week post-breeding and remained at high values throughout the pregnancy period. Immunohistochemical localization of inhibin alpha, betaA, betaB and steroidogenic enzymes cytochrome P450 aromatase, 3alpha-hydroxysteroid dehydrogenase (3betaHSD), cytochrome 17alpha-hydroxylase P450 and cholesterol side-chain cleavage cytochrome P450 in the cyclic and pregnant goat CL revealed positive immunoreactivity without affinity differences between the luteal and pregnancy stages. The placental syncytiotrophoblasts also showed positive staining, except for inhibin betaA and 3betaHSD. The giant binucleate cells of the placenta showed positive immunoreactions to PRL. These results suggest that the high concentrations of ir-inhibin, estradiol and PRL during late pregnancy are of placental origin and that the placenta may have a vital role in the maintenance of pregnancy, regulation of mammary growth and preparation for kidding and lactation in goats.
- 2010-04-01
著者
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WATANABE Gen
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
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TAYA Kazuyoshi
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
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Watanabe Gen
Lab. Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of Agricul
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Watanabe Gen
岐阜大学 連合獣医学研究科基礎獣医学
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Taya Kazuyoshi
岐阜大学 連合獣医学研究科基礎獣医学
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Taya K
Tokyo Univ. Agriculture And Technol. Tokyo
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Taya Kazuyoshi
日本中央競馬会競走馬総合研究所
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MANABE Noboru
Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of
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Watanabe G
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Taya K
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Taya K
Dep. Of Basic Veterinary Sci. The United Graduate School Of Veterinary Sciences Gifu Univ.
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KANDIEL Mohamed
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Toky
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SOSA Gamal
Department of Theriogenology, Faculty of Veterinary Medicine, Benha University
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ABOU EL-ROOS
Department of Theriogenology, Faculty of Veterinary Medicine, Benha University
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ABDEL-GHAFFAR Alaa
Department of Theriogenology, Faculty of Veterinary Medicine, Benha University
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LI Jun
Animal Resource Science Center, Graduated School of Agriculture and Life Science, University of Toky
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EL AZAB
Department of Theriogenology, Faculty of Veterinary Medicine, Benha University
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Taya Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Taya Kazuyoshi
中華人民共和国
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Abou El-roos
東京農工大学 農学部獣医学科獣医生理学
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Abou El-roos
Department Of Theriogenology Faculty Of Veterinary Medicine Benha University
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Taya Kazuyoshi
Laboratory Of Veterinary Physiology Tokyo University Of Agriculture And Technology
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Taya K
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Tokyo University Of Agricultur
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Sosa Gamal
Department Of Theriogenology Faculty Of Veterinary Medicine Benha University
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El Azab
Department Of Theriogenology Faculty Of Veterinary Medicine Benha University
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Manabe Noboru
Graduate School Of Agricultural And Life Sciences Univ. Of Tokyo
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Manabe Noboru
Animal Resource Center The University Of Tokyo:research Center. For Food Safety The University Of To
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Manabe Noboru
Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Manabe Noboru
Animal Resource Science Center Graduated School Of Agriculture And Life Science University Of Tokyo
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Watanabe Gen
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Manabe Noboru
Animal Resource Science Center The University Of Tokyo
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Taya Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Tokyo University Of Agricultur
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Kandiel Mohamed
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Kandiel Mohamed
東京農工大学 農学部獣医学科獣医生理学
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Abdel-ghaffar Alaa
Department Of Theriogenology Faculty Of Veterinary Medicine Benha University
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Li Jun
Animal Resource Science Center Graduated School Of Agriculture And Life Science University Of Tokyo
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Watanabe Gen
中華人民共和国
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Taya Kazuyoshi
東京農工大学 農学部獣医学科獣医生理学
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Manabe Noboru
Animal Resource Sci. Center Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Takano Kaoru
Laboratory Of Experimental Animal Models Division Of Bioresources National Institute Of Biomedical I
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Takimoto Kazuhiro
Department Of Veterinary Science National Institute Of Health
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Manabe Noboru
Animal Resource Sci. Center Veterinary Medical Sci. The Univ. Of Tokyo
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Tago Kazumi
Hatano Research Institute Food And Drug Safety Center
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Watanabe Gen
Laboratories Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of
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Li Jun
Animal Resource Science Center Graduate School Of Agriculture And Life Science University Of Tokyo
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KANDIEL Mohamed
Department of Theriogenology, Faculty of Veterinary Medicine, Benha University
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