Effects of 3-Methyl-4-Nitrophenol in Diesel Exhaust Particles on the Regulation of Reproductive Function in Immature Female Japanese Quail (Coturnix japonica)
スポンサーリンク
概要
- 論文の詳細を見る
In a previous study, we found that 3-methyl-4-nitrophenol (PNMC), a component of diesel exhaust particles and also a degradation product of the insecticide fenitrothion, exhibits reproductive toxicity in the adult male Japanese quail. The present study investigated the toxicity of PNMC in the female Japanese quail and its ability to influence reproduction in immature females. The quail (21-day-old) were injected intramuscularly (im) with PNMC at doses 0.1, 1, or 10 mg/kg body weight daily for 3 days. There was no significant difference in body growth between the PNMC-administered and control birds. However, the weights of the oviducts were significantly lower in the PNMC-treated birds at all doses. Furthermore, the plasma concentrations of luteinizing hormone (LH) and estradiol-17? were significantly decreased with 1 and 10 mg/kg of PNMC. These findings suggest that PNMC might influence the hypothalamo-pituitary-gonadal axis with decreasing in secretion of GnRH, LH, and ovarian steroid hormones and subsequently disturb growth of the reproductive organs of immature female quail. This study indicates that PNMC induces reproductive toxicity at the central level and disrupts reproductive function in the immature female quail.
- 日本繁殖生物学会の論文
著者
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TANEDA Shinji
Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for
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SUZUKI Akira
Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for
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Taneda Shinji
Ecological Effect Research Team Dioxin And Environmental Endocrine Disrupter Research Project Nation
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Taneda Shinji
岐阜大学 連合獣医学研究科基礎獣医学連合講座
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Taneda Shinji
Environmental Nanotoxicology Section Res. Center For Environmental Risk National Inst. For Environme
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Taneda Shinji
中華人民共和国
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Li Chunmei
国立環境研究所環境リスク研究センター
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WATANABE Gen
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu Uni
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TAYA Kazuyoshi
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu Uni
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Li Chun
Laboratory Of Animal Reproduction College Of Animal Science And Technology Nanjing Agricultural Univ
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Li Chunmei
Department Of Pathology Graduate School Of Medical Sciences Nagoya City University
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Furuta Chie
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu Univ
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Suzuki Akira
Environmental Nanotoxicology Section Research Center For Environmental Risk National Institute For E
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TAKAHASHI Shinji
Ecological Effect Research Team, Dioxin and Environmental Endocrine Disrupter Research Project, Nati
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Li Chunmei
Department Of Basic Veterinary Science The United Graduate School Of Veterinary Sciences Gifu Univer
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Watanabe Gen
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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Taya Kazuyoshi
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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FURUTA Chie
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University
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