Endocrine Mechanisms Responsible for Different Follicular Development During the Estrous Cycle in Hatano High- and Low-avoidance Rats
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概要
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Hatano high- and low-avoidance rats (HAA and LAA strains, respectively) were selected and bred according to the avoidance rate in a shuttle-box task. Although they have clear strain differences in ovarian function, their endocrine mechanisms still remain to be clarified. Differences in female reproductive endocrinology between the strains were investigated by means of measuring the plasma concentration of reproductive hormones during the estrous cycle. LAA rats showed approximately threefold lower basal and surge levels of LH, a more than fourfold lower level of FSH surges and higher levels of inhibin A and inhibin B during the estrous cycle compared with the levels seen in HAA rats. The concentration of estradiol-17β in the proestrous stage was significantly lower in LAA rats than in HAA rats. Additionally, LH and FSH secretions from primary cultured anterior pituitary cells with or without in vitro GnRH stimulation were lower in the cells derived from LAA rats and, in terms of FSH secretion, were unresponsive to GnRH in contrast to cells derived from HAA rats. Although an increased number of preantral follicles in diestrus were observed in LAA rats, number of hCG-induced ovulation was lower in LAA rats. LAA rats may have much more follicle growth during the early stage of folliculogenesis, but most follicles might not grow into mature follicles. These results strongly suggest that the strain difference in ovarian function of these two Hatano rats is due to the difference in the regulation of hypothalamo-hypophyseal system for gonadotropins secretion.
- 日本繁殖生物学会の論文
- 2011-12-01
著者
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Taya K
Tokyo Univ. Agriculture And Technol. Tokyo
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Watanabe G
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Taya K
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Taya Kazuyoshi
中華人民共和国
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Shirota Mariko
Hatano Res. Inst. Food And Drug Safety Center
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Shirota M
Hatano Research Institute Food And Drug Safety Center
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Shirota Mariko
Research Institute Of Biosciences And High-tech Research Center Azabu University
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Ohta Ryo
Safety Testing Laboratory Research Administration Hatano Research Institute Food And Drug Safety Cen
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Taya Kazuyoshi
東京農工大学 農学部獣医学科獣医生理学
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Nakamura Katsuhiro
Daiichi Fine Chemical Co. Ltd. Toyama Jpn
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NAGAOKA Kentaro
Department of Animal Breeding, Graduate School of Agricultural and Life Sciences, University of Toky
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Ohta Ryo
Safety Testing Laboratory Food And Drug Safety Center Hatano Research Institute
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Watanabe Gen
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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AKIEDA-ASAI Sayaka
Department of Basic Science, United Graduate School of Veterinary Sciences, Gifu University
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Tago Kazumi
Hatano Research Institute Food And Drug Safety Center
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Jaroenporn Sukanya
Primate Research Unit Department Of Biology Faculty Of Science Chulalongkorn University
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Taya Kazuyoshi
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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Shirota Mariko
Laboratory Of Comparative Toxicology School Of Veterinary Medicine Azabu University
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Akieda Asai
Department Of Basic Science United Graduate School Of Veterinary Sciences Gifu University
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OHTA Ryo
Division of Genetic Toxicology, Hatano Research Institute, Food and Drug Safety Center
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HORII Yasuyuki
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University
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AKIEDA ASAI
Frontier Science Research Center, University of Miyazaki
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WANG KaiMing
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
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Horii Yasuyuki
Department Of Basic Veterinary Science The United Graduate School Of Veterinary Sciences Gifu University
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Ohta Ryo
Division Of Genetic Toxicology Hatano Research Institute Food And Drug Safety Center
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Jaroenporn Sukanya
Primate Research Unit Department Of Biology Faculty Of Science Chulalongkom University
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Wang Kaiming
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo University Of Agriculture And Technology
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AKIEDA-ASAI Sayaka
Frontier Science Research Center, University of Miyazaki
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