Hatano高回避および低回避ラットにみられるゲニステインの経母体暴露の影響
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概要
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Hatano high- and low-avoidance (HAA and LAA) rats are separated by breeding from Sprague-Dawley rats by high versus low rates of avoidance responses in a shuttle-box task. In addition, compared to HAA rats, LAA rats show lower running-wheel activity, later sexual maturation, 5-day estrous cycling, lower sperm motility, more pronounced immunological reactions, and are generally less reactive to stress. The present study was designed to compare the effects of transmaternal exposure to genistein on these characteristics between HAA and LAA rats. To this aim, litters from both strains were fostered onto Sprague-Dawley rats receiving genistein by gavage with 5 mg/animal/day from day 17 of pregnancy through day 21 of lactation. Inhibited growth after weaning and reduced uterine weight at weaning were observed in the LAA offspring reared by genistein-treated dams. IgM antibody production in response to sheep red blood cells was significantly decreased in the HAA offspring reared by genistein-treated dams. During restraint stress, the plasma concentration of corticosterone was significantly lower in the LAA offspring reared by genistein-treated dams. Strain-related differences were detected in shuttle-box avoidance performance, running-wheel activity, estrous cycling, and sperm motility. The results demonstrate that transmaternal exposure to genistein potentially affects the immunological and stress responses as well as the post-weaning growth of the offspring. It suggests that a comparative study using Hatano rats would be useful for studying the influence of endocrine active chemicals on the whole body systems.
- 社団法人 日本実験動物学会の論文
著者
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太田 亮
(財)食品薬品安全センター秦野研究所
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太田 亮
食品薬品安全センター
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太田 亮
秦野研究所 遺伝学研究室
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Shirota Mariko
Hatano Research Institute, Food and Drug Safety Center
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Seki Takayuki
Hatano Research Institute, Food and Drug Safety Center
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Furuya Mami
Hatano Research Institute, Food and Drug Safety Center
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Shindo Tomoko
Hatano Research Institute, Food and Drug Safety Center
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Ono Hiroshi
Hatano Research Institute, Food and Drug Safety Center
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Kanazawa Yukiko
Hatano Res. Inst. Food And Drug Safety Center
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太田 亮
Hatano Research Institute, Food and Drug Safety Center
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代田 眞理子
Hatano Research Institute, Food and Drug Safety Center
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金澤 由基子
Hatano Research Institute, Food and Drug Safety Center
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KOJIMA Kohichi
Hatano Research Institute, Food and Drug Safety Center
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ASAI Sayaka
Faculty of Agriculture, Tokyo University of Agriculture and Technology
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WATANABE Gen
Faculty of Agriculture, Tokyo University of Agriculture and Technology
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TAYA Kazuyoshi
Faculty of Agriculture, Tokyo University of Agriculture and Technology
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Seki Takayuki
Hatano Res. Inst. Food And Drug Safety Center
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OHTA Ryo
Hatano Research Institute, Food and Drug Safety Center
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Shirota Mariko
Hatano Res. Inst. Food And Drug Safety Center
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Furuya Mami
Hatano Res. Inst. Food And Drug Safety Center
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Ohta Ryo
Hatano Res. Inst. Food And Drug Safety Center
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Kojima Kohichi
Hatano Res. Inst. Food And Drug Safety Center
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太田 亮
食品薬品安全センター秦野研究所・生殖生物学研究室
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Shindo Tomoko
Hatano Res. Inst. Food And Drug Safety Center
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Ono Hiroshi
Hatano Res. Inst.
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