Effects of Vertically Transferred 3,3',4,4',5-Pentachlorobiphenyl (PCB-126) on the Reproductive Development of Female Rats
スポンサーリンク
概要
- 論文の詳細を見る
In order to study the effects of vertically transferred coplanar polychlorinated biphenyls on female reproductive development, female rat offspring from dams of Sprague-Dawley strain, which received daily oral administration of vehicle (corn oil) or 1 or 3 μg/kg of 3,3,4,4,5-pentachlorobiphenyl (PCB-126) from 2 weeks prior to mating with intact m0ales until 20 days after delivery were examined from birth until puberty. Hepatic expression of the aryl hydrocarbon receptor (AhR)-inducible enzyme cytochrome P450 1A1 (CYP1A1) was detected in all offspring from PCB-126-exposed dams, indicating vertical transfer of PCB-126. Furthermore, quantification of ovarian mRNAs encoding CYP1A1, AhR and ARNT demonstrated that the ovary equipped the AhR-signaling system through which transcription of the CYP1A1 gene was enhanced in a dose-dependent manner. Exposure to PCB-126 retarded the growth of offspring in both exposed groups, while the viability of the neonates of the exposed groups was comparable to that of the oil-exposed controls. The exposure to 3 μg/kg/day reduced the ovarian weight on postnatal day (PND) 24, with atresia of most of the antral follicles and delayed vaginal opening. Exposure to 1 μg/kg/day did not produce such effects; however, both doses of PCB-126 induced external urogenital anomalies, such as vaginal thread and hypospadias, in all of the PCB-126-exposed female offspring. These results indicate that vertically transferred PCB-126 is potent enough to exert a direct effect on the ovary and adversely affect female puberty by altering the morphological and functional development of the female reproductive system.
- 日本繁殖生物学会の論文
- 2006-12-01
著者
-
Shirota Mariko
Hatano Res. Inst. Food And Drug Safety Center
-
Shirota M
Hatano Research Institute Food And Drug Safety Center
-
SHIROTA Kinji
Research Institute of Biosciences, Azabu University
-
SAKURADA Yosuke
Research Institute of Biosciences and High-Tech Research Center, Azabu University
-
INOUE Kaoru
Research Institute of Biosciences and High-Tech Research Center, Azabu University
-
SHIROTA Mariko
Research Institute of Biosciences and High-Tech Research Center, Azabu University
-
Sakurada Yosuke
Research Institute Of Biosciences And High-tech Research Center Azabu University
-
Sakurada Yosuke
Research Center Kyorin Pharmaceutical Co. Ltd.
-
Inoue Kaoru
Division Of Pathology National Institute Of Health Sciences
-
Shirota Kinji
Research Institute Of Biosciences And High-tech Research Center Azabu University
-
Shirota Mariko
Research Institute Of Biosciences And High-tech Research Center Azabu University
-
Akahori Fumiaki
Research Institute Of Biosciences And High-tech Research Center Azabu University
-
Haishima Atsuko
Research Institute Of Biosciences Azabu University
-
MUKAI Motoko
Research Institute of Biosciences, Azabu University
-
DOYAMA Ari
Research Institute of Biosciences, Azabu University
-
Doyama Ari
Research Institute Of Biosciences Azabu University
-
Inoue Kaoru
Research Institute Of Biosciences And High-tech Research Center Azabu University
-
Mukai Motoko
Research Institute Of Biosciences And High-tech Research Center Azabu University
関連論文
- Screening of toxicological properties of 4-methylbenzoic acid by oral administration to rats
- Hatano高回避および低回避ラットにみられるゲニステインの経母体暴露の影響
- Hatano高回避および低回避ラットにみられる免疫機能の系統差
- First Case Report of Histoplasmosis in a Cat in Japan
- Comparison of Aryl Hydrocarbon Receptor Gene Expression in Laser Dissected Granulosa Cell Layers of Immature Rat Ovaries
- INFLUENCE OF DI-(2-ETHYLHEXYL) PHTHALATE ON FETAL TESTICULAR DEVELOPMENT BY ORAL ADMINISTRATION TO PREGNANT RATS
- Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model
- Long-Term Treatment with Bromocriptine Inhibits Endometrial Adenocarcinoma Development in Rats
- Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods-a preliminary study
- Busulfan胎生期曝露による第一次卵胞減少はDonryuラットの子宮発癌を促進する
- A Case of Canine Vasotropic and Vasoinvasive Nonepitheliotropic Lymphoma with Unusual Tumor Cells and Extensive Dermal Necrosis(Pathology)
- Membranoproliferative Glomerulonephritis in a Young Cat(Pathology)
- Pathology: Progression of glomerulonephritis to end-stage kidney disease in a cat with nephrotic syndrome
- Auricular Chondritis Associated with Systemic Joint and Cartilage Inflammation in a Cat(Pathology)
- Congenital Cutaneous Fibropapillomatosis with No Evidence of Papillomavirus Infection in a Piglet
- Rhabdomyosarcoma in the Abdominal Cavity of a 12-Month-Old Female Donryu Rat
- A Case of Canine Cutaneous Clear Cell Adnexal Carcinoma with Prominent Expression of Smooth Muscle Actin
- Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassay
- Effects of Vertically Transferred 3,3',4,4',5-Pentachlorobiphenyl (PCB-126) on the Reproductive Development of Female Rats
- Effects of Vertically Transferred 3,3',4,4',5-Pentachlorobiphenyl on Gene Expression in the Ovaries of Immature Sprague-Dawley Rats
- Reduction of Primordial Follicles Caused by Maternal Treatment with Busulfan Promotes Endometrial Adenocarcinoma Development in Donryu Rats
- Gene Expression Profiling and Cellular Distribution of Molecules with Altered Expression in the Hippocampal CA1 Region after Developmental Exposure to Anti-Thyroid Agents in Rats
- Utilization of a Computer-Assisted Sperm Motion Analysis System to Examine Effects of Dinoseb on Rat Sperm
- CHRONOLOGICAL CHANGES OF ESTROUS CYCLE IN SPRAGUE-DAWLEY RATS
- 2C-05 Influences of Corn Oil and Diets on Parturition and Lactation in Rats
- Collaborative work on evaluation of ovarian toxicity : 5) Two- or four-week repeated-dose studies and fertility study of busulfan in female rats
- "Assays, methodologies and risk assessment for endocrine disruptors in relation to product development" : Assessment of Ovarian Toxicity of Chemicals in Infantile Rats (PANEL DISCUSSION: ASSAYS, METHODOLOGIES AND RISK ASSESSMENT OF ENDOCRINE DISRUPTORS IN
- Pathological Characterization of Collagenofibrotic Glomerulonephropathy in a Young Dog
- Early-Onset Podocyte Injury and Glomerular Sclerosis in Osborne-Mendel Rats
- Lack of chronic toxicity and carcinogenicity of dietary administrated catechin mixture in Wistar Hannover GALAS rats
- Distribution of VEGF and flt-1 in the Normal Dog Tissues(Pathology)
- Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats
- Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats
- Cutaneous Clear Cell Adnexal Carcinoma in a Dog: Special Reference to Cytokeratin Expression
- Lack of chronic toxicity and carcinogenicity of dietary administrated catechin mixture in Wistar Hannover GALAS rats
- Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats
- Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats
- シャトルボックス条件回避行動時におけるHatano高回避系および低回避系ラットの内分泌学的系統差
- Estrogen and androgen receptor status in hepatocellular hypertrophy induced by phenobarbital, clofibrate, and piperonyl butoxide in F344 rats
- Endocrine Mechanisms Responsible for Different Follicular Development During the Estrous Cycle in Hatano High- and Low-avoidance Rats
- Cutaneous Hybrid Cyst in a Sprague-Dawley Rat
- Rhabdomyosarcoma in the Abdominal Cavity of a 12-Month-Old Female Donryu Rat
- Membranoproliferative Glomerulonephritis in a Young Cat
- A Case of Canine Cutaneous Clear Cell Adnexal Carcinoma with Prominent Expression of Smooth Muscle Actin
- Atypical Canine Mammary Adenoma Characterized by Cystic Ducts Comprising a Single Layer of Basaloid Cells with Myoepithelial Differentiation
- Spontaneous Tyzzer's Disease with the Central Nerve Involvement in a Newborn Common Marmoset
- The Kidneys of Infant Mice are not Sensitive to the Food Mycotoxin Contaminant Nivalenol
- Granulomatous Pododermatitis in the Digits Caused by Fusarium proliferatum in a Cat
- Change in the gene expression of the N-methyl-D-aspartate receptor 2C subunit by dietary β-naphthoflavone, indole-3-carbinol, or acetaminophen in the rat liver
- A 13-week subchronic toxicity study of grape skin extract in F344 rats