A Case of Canine Cutaneous Clear Cell Adnexal Carcinoma with Prominent Expression of Smooth Muscle Actin
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概要
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Cutaneous clear cell adnexal carcinoma was found in the right lip of a 14-year-old male castrated Shih Tzu. Histologically, the tumor mostly consisted of neoplastic cells with clear or vacuolated cytoplasms and contained frequent tubular structures. Neoplastic cells showed coexpression of pan-cytokeratin (CK) and vimentin by double-labeled immunofluorescence staining. In addition, immunohistochemistry revealed that the tumor cells were positive for pan-CK (AE1/AE3, KL1, CAM 5.2), CK-7, CK-8, CK-14, CK-15, CK-18, vimentin and alpha-smooth muscle actin (SMA) with varied intensity and positivity. Among these marker proteins, SMA was positive in 75% of the tumor cells. On the other hand, CK-15, which is a specific marker of follicular stem cells, was expressed in less than 1% of the tumor cells. Based on these findings, the tumor showed diverse differentiation in apocrine sweat glands and the inner and outer root sheaths of hair follicles, indicating the follicular stem cell to be the origin of this tumor.
- 2010-12-01
著者
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Kamiie Junichi
Laboratory Of Veterinary Pathology Azabu University
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Shirota Kinji
Research Institute Of Biosciences And High-tech Research Center Azabu University
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OHMURO Tamio
Ohmuro Veterinary Clinic
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Sakuma Akiko
Research Institute of Biosciences, Azabu University
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Yasuno Kyohei
Azabu Univ. Kanagawa
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Yasuno Kyohei
Research Institute Of Biosciences Azabu University
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Nishiyama Shoko
Research Institute Of Biosciences School Of Veterinary Medicine Azabu University
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Sakuma Akiko
Research Institute Of Biosciences School Of Veterinary Medicine Azabu University
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NISHIYAMA Shoko
Research Institute of Bioscience, Azabu University
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