Cutaneous Clear Cell Adnexal Carcinoma in a Dog: Special Reference to Cytokeratin Expression
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概要
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A 5-year-old, male Bichon-Frise dog presented with a cutaneous mass in the basal region of the auricle. Histologically, the cutaneous neoplasm was comprised of lobules with solid cellular proliferation separated by thin fibrous septa. Neoplastic cells varied in size, with moderate to abundant amounts of PAS-positive cytoplasm, large nuclei and prominent nucleoli. Immunohistochemical examinations showed that tumor cells were positive for pan-cytokeratin (CK) (AE1/AE3 and CAM5.2), CK8 and CK18, but negative for pan-CK (KL1), CK7, CK14, CK16 and CK20. Double-labeled immunofluorescence testing indicated that neoplastic cells frequently co-expressed CK and vimentin, suggesting divergent differentiation of tumor cells. Based on these findings, the tumor was diagnosed as canine clear cell adnexal carcinoma.
- 社団法人 日本獣医学会の論文
著者
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SHIROTA Kinji
Research Institute of Biosciences, Azabu University
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Shirota Kinji
Research Institute Of Biosciences And High-tech Research Center Azabu University
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YASUNO Kyohei
Research Institute of Biosciences, Azabu University
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Ogihara Kikumi
Laboratory Of Environmental Pathology Azabu University
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Nishiyama Shoko
Research Institute of Biosciences, Azabu University
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Yasuno Kyohei
Azabu Univ. Kanagawa
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SUETSUGU Fumio
Maria Pet Clinic
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MADARAME Hiroo
Veterinary Teaching Hospital, Azabu University
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Ogihara Kikumi
Laboratories Of Environmental Pathology
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Yasuno Kyohei
Research Institute Of Biosciences Azabu University
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Nishiyama Shoko
Research Institute Of Biosciences School Of Veterinary Medicine Azabu University
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NISHIYAMA Shoko
Research Institute of Bioscience, Azabu University
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