Distribution of VEGF and flt-1 in the Normal Dog Tissues(Pathology)
スポンサーリンク
概要
- 論文の詳細を見る
Angiogenesis is essential for tumor progression and is regulated by several angiogenic factors such as vascular endothelial growth factor (VEGF). We investigated the expression and distribution of VEGF and its receptor flt-1 in twelve normal canine tissues in six beagle dogs using immunohistochemistry, RT-PCR and real-time RT-PCR. Immunochemical staining showed that both VEGF and flt-1 were expressed in many tissues and their mRNAs were detected in all organs examined by RT-PCR. Levels of VEGF164 and flt-1 mRNA expression were high in tissues containing many intensely immunopositive cells. The expression levels of VEGF164 and flt-1 mRNA tended to be similar. These results indicated that VEGF and flt-1 are closely associated in canine, as in human tissues, and quantifying their mRNAs might be helpful in evaluating angiogenesis.
- 社団法人日本獣医学会の論文
- 2008-11-25
著者
-
Sakurada Yosuke
Research Center Kyorin Pharmaceutical Co. Ltd.
-
Sakurada Yosuke
Research Institute Of Biosciences Azabu University
-
Shirota Kinji
Research Institute Of Biosciences And High-tech Research Center Azabu University
-
Shirota Kinji
Azabu Univ. Kanagawa Jpn
-
UCHIDA Naohiro
Research Institute of Biosciences, Azabu University
-
Uchida Naohiro
Research Institute Of Biosciences Azabu University
-
Uchida Naohiro
Azabu Univ. Kanagawa
-
NAGAI Kayoko
Research Institute of Biosciences, Azabu University
-
Nagai Kayoko
Research Institute Of Biosciences Azabu University
関連論文
- First Case Report of Histoplasmosis in a Cat in Japan
- Comparison of Aryl Hydrocarbon Receptor Gene Expression in Laser Dissected Granulosa Cell Layers of Immature Rat Ovaries
- A Case of Canine Vasotropic and Vasoinvasive Nonepitheliotropic Lymphoma with Unusual Tumor Cells and Extensive Dermal Necrosis(Pathology)
- Membranoproliferative Glomerulonephritis in a Young Cat(Pathology)
- Auricular Chondritis Associated with Systemic Joint and Cartilage Inflammation in a Cat(Pathology)
- Congenital Cutaneous Fibropapillomatosis with No Evidence of Papillomavirus Infection in a Piglet
- A Case of Canine Cutaneous Clear Cell Adnexal Carcinoma with Prominent Expression of Smooth Muscle Actin
- Effects of Vertically Transferred 3,3',4,4',5-Pentachlorobiphenyl (PCB-126) on the Reproductive Development of Female Rats
- Effects of Vertically Transferred 3,3',4,4',5-Pentachlorobiphenyl on Gene Expression in the Ovaries of Immature Sprague-Dawley Rats
- Collaborative work on evaluation of ovarian toxicity : 5) Two- or four-week repeated-dose studies and fertility study of busulfan in female rats
- "Assays, methodologies and risk assessment for endocrine disruptors in relation to product development" : Assessment of Ovarian Toxicity of Chemicals in Infantile Rats (PANEL DISCUSSION: ASSAYS, METHODOLOGIES AND RISK ASSESSMENT OF ENDOCRINE DISRUPTORS IN
- Pathological Characterization of Collagenofibrotic Glomerulonephropathy in a Young Dog
- Early-Onset Podocyte Injury and Glomerular Sclerosis in Osborne-Mendel Rats
- Distribution of VEGF and flt-1 in the Normal Dog Tissues(Pathology)
- Cutaneous Clear Cell Adnexal Carcinoma in a Dog: Special Reference to Cytokeratin Expression
- Cutaneous Hybrid Cyst in a Sprague-Dawley Rat
- Membranoproliferative Glomerulonephritis in a Young Cat
- A Case of Canine Cutaneous Clear Cell Adnexal Carcinoma with Prominent Expression of Smooth Muscle Actin
- Atypical Canine Mammary Adenoma Characterized by Cystic Ducts Comprising a Single Layer of Basaloid Cells with Myoepithelial Differentiation
- Spontaneous Tyzzer's Disease with the Central Nerve Involvement in a Newborn Common Marmoset
- Granulomatous Pododermatitis in the Digits Caused by Fusarium proliferatum in a Cat