Early-Onset Podocyte Injury and Glomerular Sclerosis in Osborne-Mendel Rats

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概要

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• Progressive glomerular injury associated with early-onset proteinuria was investigated in male Osborne-Mendel (OM) rats aged 5 to 20 weeks. Age-matched male Fischer 344 (F344) rats were used for comparison. OM rats developed mild hypertension and selective proteinuria (albuminuria) from 5 weeks of age, and non-selective proteinuria from 7 weeks of age. Light microscopy of OM kidney revealed hyaline droplets in the podocyte at 5 weeks of age and vacuolation of podocytes and adhesion of the capillary loop to the Bowmans capsule at 7 weeks of age. Segmental glomerulosclerosis developed in the OM rats from 15 weeks of age, and global sclerosis appeared at 20 weeks of age. Desmin, a marker of podocye injury, was expressed in podocytes from 10 weeks of age, and the intensity of expression increased with age. Ultrastructurally, damage to podocytes such as effacement of foot processes and filtration slits, and rearrangement of the actin cytoskeleton were observed from 5 weeks of age in the OM rat. Glomerular volume in OM rats increased with age and was consistently higher than in age-matched F344 rats. The number of WT-1-positive podocytes and vimentin-positive podocyte area were lower in OM rats and decreased with age. These findings suggest that glomerulonephropathy in male OM rats is associated with glomerular hypertrophy, progressive podocytopathy, and a reduction in podocyte number and area. Renal injury in OM rats was associated with development of early-onset proteinuria and was more progressive than in age-matched F344 rats.

著者

• Baba Tomoshige

  Research Institute Of Biosciences Azabu University

• Kamiie Junichi

  Laboratory Of Veterinary Pathology Azabu University

• Kobayashi Ryosuke

  Research Institute of Biosciences, Azabu University

• Shirota Kinji

  Research Institute Of Biosciences And High-tech Research Center Azabu University

• YASUNO Kyohei

  Research Institute of Biosciences, Azabu University

• Ogihara Kikumi

  Laboratory Of Environmental Pathology Azabu University

• ISHIKAWA MAKOTO

  Research & Development Division, Taiko Refractories Co., Ltd.

• Yasuno Kyohei

  Azabu Univ. Kanagawa

• ISHIHARA Shoko

  Research Institute of Biosciences, Azabu University

• SAITO Rio

  Research Institute of Biosciences, Azabu University

• KATO Takashi

  Research Institute of Biosciences, Azabu University

• KAWANO Kazuya

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

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