Effects of Diesel Exhaust Particles on the Male Reproductive System in Strains of Mice with Different Aryl Hydrocarbon Receptor Responsiveness
スポンサーリンク
概要
- 論文の詳細を見る
Diesel exhaust particles (DEPs) contain polycyclic aromatic hydrocarbons (PAH) that bind to aryl hydrocarbon receptors (AhRs) and decrease sperm production. Since it is not clear if AhR mediates DEP toxicity, we investigated the effect of DEPs in four strains of mice that have different AhR responsiveness. We treated BALB/c, C57BL/6, ICR and DBA/2 mice with DEP suspensions and compared their toxicity in each strain. In both the vehicle- and DEP-treated groups, ethoxyresorufin-O-deethylase (EROD) activity, as an indirect index of AhR activity, was increased in the order of BALB/c > C57BL/6 > ICR > DBA/2. Only BALB/c and C57BL/6 mice had significantly lower daily sperm production (DSP) than vehicle-treated mice. All strains exhibited increased sperm abnormalities. In particular, the C57BL/6, ICR and DBA/2 mice exhibited significantly increased abnormalities. A significant correlation was found between EROD activity and DSP or incidence of morphologically abnormal sperm. These data suggest that DEP toxicity may affect the male reproductive system in an AhR-dependent manner.
- 日本繁殖生物学会の論文
- 2007-12-01
著者
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Watanabe Gen
Lab. Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of Agricul
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Taya K
Tokyo Univ. Agriculture And Technol. Tokyo
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Taya K
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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WATANABE Gen
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu Uni
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TAYA Kazuyoshi
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu Uni
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Taya Kazuyoshi
中華人民共和国
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Sagai Masaru
Dep. Of Life Sciences Graduate School Of Health Sciences Aomori Univ. Of Health And Welfare
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Takano Kaoru
Laboratory Of Experimental Animal Models Division Of Bioresources National Institute Of Biomedical I
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Kohara Machiko
Department Of Life Sciences Graduate School Of Health Sciences Aomori University Of Health And Welfa
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Sagai Masaru
Division Of Human Sciences Faculty Of Health Sciences Aomori University Of Health And Welfare
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Izawa Hiromi
Division Of Human Sciences Faculty Of Health Sciences Aomori University Of Health And Welfare
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Watanabe Gen
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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Taya Kazuyoshi
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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