Increased Deoxycytidine Kinase Activity by Etoposide in L1210 Murine Leukemic Cells
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概要
- 論文の詳細を見る
Deoxycytidine kinase (dCK) is a rate-limiting enzyme for the activation of ara-C. It is responsible for the phosphorylation of ara-C which is widely used in the treatment of leukemia. We examined the effect of etoposide on dCK in L1210 cells and found that incubation with 10 μM etoposide for 1 h increased dCK activity to 170% of the control. This effect of etoposide on dCK activity was concentration-dependent up to at least 100 μM of the substance.
- 公益社団法人日本薬学会の論文
- 1996-10-15
著者
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SAKURAI MINORU
Department of Orthopaedic Surgery, School of Medicine, Tohoku University
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OOI Kazuya
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Josai University
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Sakurai Minoru
Department Of Pediatrics Mie University School Of Medicine
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Kawasaki Hajime
Department Of Pediatrics Mie University School Of Medicine
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Kawasaki Hajime
Department Of Pediatrics
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Ooi Kazuya
Department Of Pharmacy Yokkaichi Social Insurance Hospital
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Ooi Kazuya
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University
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HIGASHIGAWA MASAMUNE
Department of Pediatrics, Mie University School of Medicine
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OHKUBO Toshiki
Department of Pediatrics, Mie University School of Medicine
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Higashigawa M
Mie Univ. Mie Jpn
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Higashigawa Masamune
Department Of Pediatrics Mie University School Of Medicine
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Ohkubo Toshiki
Department Of Pediatrics Mie University School Of Medicine
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Sakurai Minoru
Department Of Biomolecular Engineering Tokyo Institute Of Technology
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