グリコシル化の高効率立体制御法の開発と細菌由来糖鎖構築への応用

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概要

• 論文の詳細を見る

• オリゴ糖や多糖の合成において，グリコシル化は鍵反応として繰り返しおこなわれるため，効率性，立体選択性の両方が重要となる。また，原核生物や真核生物の由来を問わず，様々な生物活性を持つ糖鎖にみられる構造である 1,2-cis グリコシドの合成法としては，決定的なものは少ない。我々は効率性と立体選択性の両面からアプローチして，種々の手法により，1,2-cis 選択的なグリコシル化反応の高効率な立体制御法の開発に成功した。それらの手法は，細菌由来などの種々の複合糖質糖鎖の合成に応用可能であることを示した。

• FCCA(Forum: Carbohydrates Coming of Age)の論文
• 2009-09-30

著者

• Ito Yukishige

  RIKEN Advanced Science Institute and ERATO Japan Science and Technology Agency, Wako, Saitama 351-01

• Ito Yukishige

  Riken Advanced Sci. Inst. And Erato Japan Sci. And Technol. Agency Wako Saitama 351-0198 Japan

• ISHIWATA Akihiro

  RIKEN Advanced Science Institute

• Ito Yukishige

  Riken Advanced Science Institute

• Ito Yukishige

  Riken

• Ishiwata Akihiro

  Riken (the Institute Of Physical And Chemical Research)

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