Enhancing activity of anthranilic acid on adjuvant arthritis in rats and antibody formation in mice.

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概要

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• Anthranilic acid (ANA), a metabolite of tryptophan, was examined for its immunopotentiating properties. Administration of ANA (12 mg/kg/day, p.o.) significantly enhanced the development of adjuvant arthritis in rats, although not in a dose-related manner. ANA tended to enhance adjuvant disease moderately suppressed by pretreatment with cyclophosphamide (CY), an immunosuppressive agent. ANA (3-30 mg/kg/day, p.o.) also caused a dose-related enhancement in the antibody formation to sheep erythrocytes (SRBC) in mice.

• 公益社団法人 日本薬理学会の論文

著者

• Yamaguchi Yu

  Department Of Obstetrics And Gynecology Tohoku University School Of Medicine

• Kunitomo Masaru

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Yamada Kaori

  Department Of Biological Science And Technology Tokai University

• Bando Yoshio

  Department Of Anatomy 1 Asahikawa Medical College

• Tanaka Yoko

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• YAMADA Kaori

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University

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