Cholesterol reduces and corticosteroids enhance the toxicity of vitamin D in rats.
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概要
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The effect of a high-cholesterol (CHOL) diet and corticosteroids on the toxicity of vitamin D<SUB>2</SUB> (VD<SUB>2</SUB>) in rats was studied. VD<SUB>2</SUB> was administered orally at the dosage of 5-60×10<SUP>4</SUP> IU/kg, once daily for 4 days. Animals fed CHOL showed a decrease in mortality due to VD<SUB>2</SUB> treatment. Dietary CHOL inhibited toxic responses such as a diminished growth rate following anorexia, elevated serum calcium level and calcium deposition in tissues, which were produced by a sublethal dose of VD<SUB>2</SUB> (20×10<SUP>4</SUP> IU/kg, once daily for 4 days). Animals pretreated with the high-CHOL diet from 2 weeks before the first VD<SUB>2</SUB> administration showed much more symptomatic relief than those given this diet after the first VD<SUB>2</SUB> administration. On the other hand, dexamethasone (DEX) as well as corticosterone remarkably increased the mortality due to VD<SUB>2</SUB>. The degree of VD<SUB>2</SUB> toxicity, enhanced by DEX, was correlated with the degree of hypercalcemia and tissue calcification. Therefore, the inhibitory effect of CHOL is not likely to be due to activation of the CHOL-corticosterone system in the adrenal gland.
- 公益社団法人 日本薬理学会の論文
著者
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Yamaguchi Yu
Department Of Obstetrics And Gynecology Tohoku University School Of Medicine
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Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Bando Yoshio
Department Of Anatomy 1 Asahikawa Medical College
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Tanaka Yoko
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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BANDO Yoshio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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FUTAGAWA Yoshiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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