Cholesterol metabolism in serum and aorta of inbred mice fed a high-cholesterol diet.
スポンサーリンク
概要
- 論文の詳細を見る
Biochemical characterization of the serum and aorta in inbred C57BL/6Cr mice fed a high-cholesterol diet was investigated by determining the total cholesterol (TC) and free cholesterol (FC) levels in serum, high density lipoprotein (HDL) and aorta. Serum lecithin:cholesterol acyltransferase (LCAT) activity was also determined. A modified fluoroenzymatic method for microdetermination of cholesterol was successfully used. TC and FC levels of the aorta in the mice were significantly increased by the high-cholesterol diet. Serum TC and FC levels of mice fed the high-cholesterol diet were increased about 80% and 110%, respectively, compared with the control. On the other hand, both HDL-TC and HDL-FC levels were decreased about 50%. The HDL-TC/serum-TC ratio was markedly decreased, while the atherogenic index was markedly increased with the high-cholesterol diet. LCAT activity was also strikingly decreased. A positive correlation was observed between LCAT activity and HDL-cholesterol. These changes in the serum may facilitate cholesterol accumulaticn in the aorta. The results indicate that a biochemical approach using mice may be possible for drug evaluation.
- 公益社団法人 日本薬理学会の論文
著者
-
Yamaguchi Yu
Department Of Obstetrics And Gynecology Tohoku University School Of Medicine
-
Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
-
Bando Yoshio
Department Of Anatomy 1 Asahikawa Medical College
-
MATSUSHIMA Kaori
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
関連論文
- Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats(Pharmacology)
- Effects of Ginkgo Biloba Extract Feeding on Salt-Induced Hypertensive Dahl Rats(Pharmacology)
- Chronic Production of Peroxynitrite in the Vascular Wall Impairs Vasorelaxation Function in SHR/NDmcr-cp Rats, an Animal Model of Metabolic Syndrome
- Long-Term Feeding of Ginkgo biloba Extract Impairs Peripheral Circulation and Hepatic Function in Aged Spontaneously Hypertensive Rats(Pharmacognosy)
- P2Y Receptor-Mediated Ca^ Signaling Increases Human Vascular Endothelial Cell Permeability
- Pharmacology and Physiology of Perivascular Nerves Regulating Vascular Function : Purinergic Modulation of Vascular Sympathetic Neurotransmission
- Characterization of Prejunctional Purinoceptors Inhibiting Noradrenaline Release in Rat Mesenteric Arteries
- Activation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats
- Inhibitory Effect of Cordyceps sinensis on Spontaneous Liver Metastasis of Lewis Lung Carcinoma and B16 Melanoma Cells
- Peroxynitrite-Generating Species: Good Candidate Oxidants in Aqueous Extracts of Cigarette Smoke
- Regional Differences in Noradrenaline-Induced Release of Adenosine Triphosphate from Rat Vascular Endothelium
- Hole-doping and Pressure Effects on the Metal-Insulator Transition in Single Crystals of Y_Ca_xTiO_3(0.37 ≤ x ≤ 0.41)(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Hole-doping and Pressure Effects on the Metal-Insulator Transition in Single Crystals of Y_Ca_xTiO_3 (0.37≦x≦0.41)
- Immunological Effects of Recombinant Feline Interferon-ω (KT-80) Administration in the Dog
- THE SIGNIFICANCE OF NONSTRESS TEST FROM 24 TO 42 WEEKS' GESTATION
- Oxidants in the Gas Phase of Cigarette Smoke Pass Through the Lung Alveolar Wall and Raise Systemic Oxidative Stress
- Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice(Pharmacognosy)
- Regeneration of the abdominal postganglionic sympathetic system
- Participation of Endogenous Noradrenaline in the Relaese of ATP by High Potassium in the Rat Caudal Artery
- EXPERIMENTAL ATHEROSCLEROSIS IN RATS FED A VITAMIN D, CHOLESTEROL-RICH DIET
- Toxicologic Investigation of Dimethylacrylamide in Mice
- FUNDAMENTAL STUDIES OF ANTHELMINTICS (XXII). ELECTROPHYSIOLOGICAL STUDIES OF 1-[2-(DODECYLOXY) ETHYL]PYRROLIDINE HYDROCHLORIDE (DEP) ON ASCARIS MUSCLE CELLS
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. VI. EFFECTS OF L-ASCORBATE 2-SULFATE ON LIPID METABOLISM IN GUINEA PIGS
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. V. ON THE HYPOLIPIDEMIC AND ANTIATHEROSCLEROTIC EFFECTS OF L-ASCORBATE 2-SULFATE IN RABBITS
- Transport and Magnetic Properties of a Low-Density Carrier System SmBiPt
- Effects of Cholesterol Loading on Autoimmune MRL-lpr/lpr Mice. Susceptibility to Hypercholesterolemia and Aortic Cholesterol Deposition.
- Pharmacological Analysis of Receptors Involved in the Late, Tachykininergic Contractile Response to Electrical Transmural Stimulation in Isolated Rabbit Iris Sphincter Muscle.
- Possible Participation of ATP in Changes of Blood Pressure in SHR and Old Rats
- Hyperlipidemic effects of adriamycin in rats.
- Suppression of adjuvant arthritis in rats by cholesterol.
- Abnormal lipid metabolism in adjuvant arthritic rats.
- Enhancing activity of anthranilic acid on adjuvant arthritis in rats and antibody formation in mice.
- Cholesterol reduces and corticosteroids enhance the toxicity of vitamin D in rats.
- P2Y Receptor-Mediated Ca2+ Signaling Increases Human Vascular Endothelial Cell Permeability
- A Uniform Alteration in Serum Lipid Metabolism Occurring during Inflammation in Mice.
- Lipid deposition in the aorta of adjuvant arthritic rats with hypercholesterolemia.
- Cholesterol metabolism in serum and aorta of inbred mice fed a high-cholesterol diet.
- Impairment of Endothelium-Dependent Relaxation in Aorta from Rats with Arteriosclerosis Induced by Excess Vitamin D and a High-Cholesterol Diet.
- Altered Vasoconstrictor Responsiveness in Vitamin D-Induced Arteriosclerotic Rat Aortas.
- Atherosclerosis mouse model induced by a high-cholesterol diet supplemented with .BETA.-aminopropionitrile: Effects of various anti-atherosclerotic agents on the biochemical parameters.