Long-Term Feeding of Ginkgo biloba Extract Impairs Peripheral Circulation and Hepatic Function in Aged Spontaneously Hypertensive Rats(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
We previously demonstrated that Ginkgo biloba extract (GBE) produces an anti-hypertensive effect via enhanced vasodilation responses in young spontaneously hypertensive rats (SHR) and hepatic hypertrophy occurs with increased cytochrome P450 (CYP) mRNA expression in young rats. In the present study, to clarify whether these actions of GBE are observed in older rats, we investigated cardiovascular functions and hepatic CYP protein expressions in aged SHR fed a control diet or a diet containing 0.5% GBE for 4 weeks. In aged SHR, GBE feeding significantly increased liver weight per 100g body weight without changing the body weight. Furthermore, significant increases in alanine aminotransferase level in serum and marked increase in CYP2B protein expression in the liver were observed in aged SHR fed GBE. On the other hand, GBE feeding did not affect blood pressure, but significantly reduced heart rate and blood flow velocity in tail arteries of aged SHR. Furthermore, GBE feeding did not affect contractile response to phenylephrine, relaxation responses to not only sodium nitroprusside but also acetylcholine, and protein levels of endothelium nitric oxide synthase and soluble guanylate cyclase in aortas of aged SHR. These results suggested that long-term GBE feeding impairs peripheral circulation due to bradycardia and hepatic function in aged SHR. Thus, in the elderly population with hypertension, the use of GBE may need to be assessed for effects on heart rate and liver function.
- 社団法人日本薬学会の論文
- 2008-01-01
著者
-
Nakamura Katsuya
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
KUBOTA Yoko
Department of Biopharmaceutics, Nihon Pharmaceutical University
-
KAGOTA Satomi
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
-
NAKAMURA Kazuki
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
-
KUNITOMO Masaru
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
-
SHINOZUKA Kazumasa
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
-
Nakamura K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Kunimoto M
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Kunitomo Masaru
京都大学 医学研究科糖尿病･栄養内科学
-
Kubota Y
Department Of Biopharmaceutics Nihon Pharmaceutical University
-
TADA Yukari
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's Univers
-
NEJIME Namie
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's Univers
-
Nakamura Kazufumi
Faculty Of Pharmaceutical Sciences Kyushu University
-
Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
-
Kunitomo Masaru
Department Of Pharmacology Shizuoka College Of Pharmaceutical Science
-
Nakamura Kazuki
Department Of Applied Chemistry Faculty Of Engineering Shibaura Institute Of Technology
-
Nakamura Katsuji
Tsukuba Research Laboratories Eisai Co. Ltd.
-
Shinozuka Kazumasa
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Shinozuka Kazumasa
Dep. Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
-
Shinozuka Kazumasa
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
-
Shinozuka Kazumasa
Department Of Pharmacology Faculty Of Pharmaceutical Science Mukogawa Women's University
-
Nakamura K
Department Of Physiology Ii Iwate Medical University School Of Medicine
-
Shinozuka K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Kwon Young
Department Of Biopharmaceutics Nihon Pharmaceutical University
-
Kagota Satomi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
-
Kunitomo Masaru
Dep. Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
-
Saito K
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
-
Tanioka Y
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
-
Tada Yukari
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
-
Nejime Namie
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
-
Shinozuka Kazumasa
Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
-
Nejime Namie
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
関連論文
- Effects of Dietary Ingredients on Function and Expression of P-Glycoprotein in Human Intestinal Epithelial Cells
- Characterization of cardiac size and function in SHRSP.Z-Lepr[fa]/IzmDmcr rats, a new animal model of metabolic syndrome
- Finite Element Stress Analysis of Spent Nuclear Fuel Disposal Canister in a Deep Geological Repository
- ON COMPLETELY REGULAR AND QUASI-COMPLETELY REGULAR ORDERED SEMIGROUPS
- Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats(Pharmacology)
- Effects of Ginkgo Biloba Extract Feeding on Salt-Induced Hypertensive Dahl Rats(Pharmacology)
- Safety of Dietary Supplements:Chronotropic and Inotropic Effects on Isolated Rat Atria
- Biochemical Evidence of Atherosclerosis Progression Mediated by Increased Oxidative Stress in Apolipoprotein E-Deficient Spontaneously Hyperlipidemic Mice Exposed to Chronic Cigarette Smoke
- Chronic Production of Peroxynitrite in the Vascular Wall Impairs Vasorelaxation Function in SHR/NDmcr-cp Rats, an Animal Model of Metabolic Syndrome
- Long-Term Feeding of Ginkgo biloba Extract Impairs Peripheral Circulation and Hepatic Function in Aged Spontaneously Hypertensive Rats(Pharmacognosy)
- P2Y Receptor-Mediated Ca^ Signaling Increases Human Vascular Endothelial Cell Permeability
- Pharmacology and Physiology of Perivascular Nerves Regulating Vascular Function : Purinergic Modulation of Vascular Sympathetic Neurotransmission
- Characterization of Prejunctional Purinoceptors Inhibiting Noradrenaline Release in Rat Mesenteric Arteries
- Activation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats
- Inhibitory Effect of Cordyceps sinensis on Spontaneous Liver Metastasis of Lewis Lung Carcinoma and B16 Melanoma Cells
- Beneficial Effect of Coenzyme Q10 on Increased Oxidative and Nitrative Stress and Inflammation and Individual Metabolic Components Developing in a Rat Model of Metabolic Syndrome
- Anion-exchange high-performance liquid chromatography assays of plasma lipoproteins and modified low-density lipoproteins using a ProtEx-DEAE column
- Peroxynitrite-Generating Species: Good Candidate Oxidants in Aqueous Extracts of Cigarette Smoke
- High-performance liquid chromatographic assay of hydroperoxide levels in oxidatively modified lipoproteins
- Anion-exchange high-performance liquid chromatographic assay of plasma lipoproteins of rabbits, rats and mice
- Regional Differences in Noradrenaline-Induced Release of Adenosine Triphosphate from Rat Vascular Endothelium
- High-Spin States in ^Nb(Nuclear physics)
- Characterization of Cardiac Size and Function in SHRSP.Z-Leprfa/IzmDmcr Rats, a New Animal Model of Metabolic Syndrome
- Highly Sensitive Measurement of P-Glycoprotein-Mediated Transport Activity in Caco-2 Cells
- Effect of Vanadate on ATP-Induced Increase in Intracellular Calcium Ion Levels in Human Umbilical Vein Endothelial Cells
- Effects of ATP on the Intracellular Calcium Level in the Osteoblastic TBR31-2 Cell Line(Biochemistry)
- Studies on Anti-inflammatory Agents. VI. Synthesis and Pharmacological Properties of 2,3-Diarylthiophenes
- Studies on Anti-inflammatory Agents. V. Synthesis and Pharmacological Properties of 3-(Difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl)phenyl]pyrazole and Related Compounds
- Studies on Anti-inflammatory Agents. IV. Synthesis and Pharmacological Properties of 1,5-Diarylpyrazoles and Related Derivatives
- Synthesis and Evaluation of Novel Pyrimido-Acridone, -Phenoxadine, and -Carbazole as Topoisomerase II Inhibitors
- A novel carbazole topoisomerase II poison, ER-37328 : potent tumoricidal activity against human solid tumors in vitro and in vivo
- Substantial role of locus coeruleus-noradrenergic activation and capsaicin-insensitive primary afferent fibers in bee venom's anti-inflammatory effect
- Oxidants in the Gas Phase of Cigarette Smoke Pass Through the Lung Alveolar Wall and Raise Systemic Oxidative Stress
- Melatonin Inhibits the Central Sympatho-adrenomedullary Outflow in Rats
- EFFECT OF SHAKUYAKU-KANZOH-TOH, A PRESCRIPTION COMPOSED OF SHAKUYAKU (PAEONIAE RADIX) AND KANZOH (GLYCYRRHIZAE RADIX) ON GUINEA PIG ILEUM
- Microfluidic Polymer Chip with an Embedded Ion-Selective Electrode Detector for Nitrate-Ion Assay in Environmental Samples
- Highly Conserved Antigenic Structure of the Factor VIII C2 Domain in Some Mammals
- Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice(Pharmacognosy)
- Activation of Inwardly Rectifying K^+ Channel in OK Proximal Tubule Cells Involves cGMP-Dependent Phosphorylation Process
- Seismic Intensity and Mental Stress after the Great Hanshin-Awaji Earthquake
- Life Events and Posttraumatic Stress in Hanshin-Awaji Earthquake Victims
- Involvement of Inducible Nitric Oxide Synthase in Blood Flow Decrease in Vein Induced by Hen-Egg White Lysozyme(Miscellaneous)
- Development of an in Vivo Bioassay Method for Allergy-Preventive Substances Using Hen-Egg White Lysozyme (HEL)-Induced Blood Flow Decrease(Miscellaneous)
- Ginkgo biloba Extract markedly Induces Pentoxyresorufin O-Dealkylase Activity in Rats
- Endothelin ET_A- and ET_B-Receptor-Mediated Inhibition of Noradrenaline Release From Isolated Rat Stomach
- Pharmaceutical and Pharmacological Evaluations of "Indometacin M Ointment" as a Pharmacy Preparation
- Modulation of the Ca^-Activated Large Conductance K^+ Channel by Intracellular pH in Human Renal Proximal Tubule Cells
- Effect of Additives on Dissolution and Swelling of Soybean Lecithin Microcapsules Prepared Using the Wurster Process
- Phase Separation in Microcapsule Membranes Composed of Soybean Lecithin, Cholesterol, Stearic Acid and Polyvinylpyrrolidone
- Regulation of Inwardly Rectifying K^+ Channel in Cultured Opossum Proximal Tubule Cells by Protein Phosphatases 1 and 2A
- Isolation and Structure of Four New Ceramides from the Starfish Luidia maculata
- Isolation and Structure Determination of Six Glucocerebrosides from the Starfish Luidia maculata
- Changes of Contractile Properties of Extensor Digitorum Longus in Response to Creatine-Analogue Administration and/or Hindlimb Suspension in Rats
- Effects of Chronic Iron Deficiency Anemia on Brain Metabolism
- Source of ATP, ADP, AMP and Adenosine Released from Isolated Rat Caudal Artery Exposed to Noradrenaline
- POSSIBILITIES FOR ADENOSINE MODULATION OF PERISTALTIC REFLEX IN GUINEA PIG ISOLATED ILEUM
- PHYSIOLOGICAL IMPLICATION OF THE L-ARGININE-NITRIC OXIDE PATHWAY IN CIRCULATION
- Role of K^+ Channels in M_2 Muscarinic Receptor-Mediated Inhibition of Noradrenaline Release From the Rat Stomach
- Product Analyses of Ozone Mediated Nitration of Benzimidazole Derivatives with Nitrogen Dioxide : Formation of 1-Nitrobenzimidazoles and Conversion to Benzotriazoles
- Participation of Endogenous Noradrenaline in the Relaese of ATP by High Potassium in the Rat Caudal Artery
- Nicotinamide Derivatives as a New Class of Gastric (H^+/K^+)-ATPase Inhibitors. III. Synthesis and Gastric Antisecretory Activity of 2-[(2- and 4-Aminobenzyl, and α-methylbenzyl)sulfinyl]-N-(4-pyridinyl)-3-pyridinecarboxamides
- Nicotinamide Derivatives as a New Class of Gastric (H^+/k^+)-ATPase Inhibitors. II. Synthesis and Structure-Activity Relationships of 2-[(2,4-Dimethoxybenzyl)sulfinyl]-N-(4-pyridinyl)pyridine-3-carboxamides
- Changes in cellular immunity during chemotherapy for testicular cancer
- THE INFLUENCE OF EXTRACELLULAR Ca2+ CONCENTRATION ON THE INHIBITORY EFFECT OF ADENOSINE IN GUINEA-PIG ILEAL LONGITUDINAL MUSCLES
- Involvement of Endogenous Nitric Oxide in the Regulation of K^+ Channel Activity in Cultured Human Proximal Tubule Cells
- EXPERIMENTAL ATHEROSCLEROSIS IN RATS FED A VITAMIN D, CHOLESTEROL-RICH DIET
- Toxicologic Investigation of Dimethylacrylamide in Mice
- FUNDAMENTAL STUDIES OF ANTHELMINTICS (XXII). ELECTROPHYSIOLOGICAL STUDIES OF 1-[2-(DODECYLOXY) ETHYL]PYRROLIDINE HYDROCHLORIDE (DEP) ON ASCARIS MUSCLE CELLS
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. VI. EFFECTS OF L-ASCORBATE 2-SULFATE ON LIPID METABOLISM IN GUINEA PIGS
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. V. ON THE HYPOLIPIDEMIC AND ANTIATHEROSCLEROTIC EFFECTS OF L-ASCORBATE 2-SULFATE IN RABBITS
- An ATP-Regulated and pH-Sensitive Inwardly Rectifying K^+ Channel in Cultured Human Proximal Tubule Cells
- Properties of a Ca^-Activated Large Conductance K^+ Channel with ATP Sensitivity in Human Renal Proximal Tubule Cells
- PHENTOLAMINE TEST FOR OPERATIVE COMPLICATIONS OF PHEOCHROMOCYTOMA : ITS PROGNOSTIC IMPORTANCE
- Preventive effects of the extract of kinka-cha, a folk tea, on a rat model of metabolic syndrome
- Effects of Functional Food Constituents on P-glycoprotein Activity in Caco-2 Cells Determined by a New Method Using Confocal Laser Scanning Microscopy
- Effects of Short-term Ginkgo Biloba Extract Feeding on Hypotensive Action of Nicardipine in Rats
- Effects of cytokines on potassium channels in renal tubular epithelia
- Effects of ATP on the Intracellular Calcium Level in the Osteoblastic TBR31-2 Cell Line
- Reaction Mechanism and Improved Performance of Solution-Based Electrochemiluminescence Cell Driven by Alternating Current
- Advantage of Immobilization of Phthalate Derivatives on Indium Tin Oxide Electrode over TiO
- Effects of Cholesterol Loading on Autoimmune MRL-lpr/lpr Mice. Susceptibility to Hypercholesterolemia and Aortic Cholesterol Deposition.
- Pharmacological Analysis of Receptors Involved in the Late, Tachykininergic Contractile Response to Electrical Transmural Stimulation in Isolated Rabbit Iris Sphincter Muscle.
- Possible Participation of ATP in Changes of Blood Pressure in SHR and Old Rats
- Changes of platelet functions due to spontaneous hypertension: Reduced responses to Ionophore A23187 in SHRSP platelets
- Hyperlipidemic effects of adriamycin in rats.
- Suppression of adjuvant arthritis in rats by cholesterol.
- Abnormal lipid metabolism in adjuvant arthritic rats.
- Enhancing activity of anthranilic acid on adjuvant arthritis in rats and antibody formation in mice.
- Cholesterol reduces and corticosteroids enhance the toxicity of vitamin D in rats.
- Changes of platelet functions due to spontaneous hypertention: Effects of OP/CPK and/or ASA on platelet aggregation in SHRSP and WKY
- Hypertensive Effects of Nitroarginine:Comparison between WKY and SHRSP
- P2Y Receptor-Mediated Ca2+ Signaling Increases Human Vascular Endothelial Cell Permeability
- Changes in Platelet Functions due to Hypertension in The Rat VI. Comparison of Experimental Hypertension with Spontaneous Hypertension
- A Uniform Alteration in Serum Lipid Metabolism Occurring during Inflammation in Mice.
- Lipid deposition in the aorta of adjuvant arthritic rats with hypercholesterolemia.
- Cholesterol metabolism in serum and aorta of inbred mice fed a high-cholesterol diet.
- Impairment of Endothelium-Dependent Relaxation in Aorta from Rats with Arteriosclerosis Induced by Excess Vitamin D and a High-Cholesterol Diet.
- Altered Vasoconstrictor Responsiveness in Vitamin D-Induced Arteriosclerotic Rat Aortas.
- Atherosclerosis mouse model induced by a high-cholesterol diet supplemented with .BETA.-aminopropionitrile: Effects of various anti-atherosclerotic agents on the biochemical parameters.
- Effect of amide bond in gate dielectric polymers on memory performance of organic field-effect transistors