Beneficial Effect of Coenzyme Q10 on Increased Oxidative and Nitrative Stress and Inflammation and Individual Metabolic Components Developing in a Rat Model of Metabolic Syndrome

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概要

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• Metabolic syndrome (MetS) is a group of cardiovascular risk factors, including visceral obesity, glucose intolerance, hypertension, and dyslipidemia. Increased oxidative and nitrative stress and inflammation and decreased endothelial function occur in an animal model of metabolic syndrome, SHR/NDmcr-cp (SHR/cp) rats. The present study investigated the effects of coenzyme Q10 (CoQ10), one of the important antioxidants, on the abnormal oxidative condition and characteristic components of metabolic syndrome in SHR/cp rats by maintaining them on a diet supplemented with 0.07% – 0.7% CoQ10 for 26 weeks. We determined serum levels of oxidatively modified low-density lipoprotein (Ox-LDL) and 8-hydroxy-2-deoxyguanosine (8-OHdG) as oxidative stress markers, 3-nitrotyrosine as a nitrative stress marker, 3-chlorotyrosine as a marker of myeloperoxidase (MPO)-catalyzed oxidation and high-sensitivity C-reactive protein (hsCRP) as an inflammatory marker. The administration of CoQ10 significantly attenuated the increase of oxidative and nitrative stress markers and inflammation markers in a dose-dependent manner. CoQ10 prevented the elevated serum insulin levels, although it did not affect the elevated glucose level and dyslipidemia. CoQ10 also reduced elevated blood pressure, but did not affect body weight gain. In addition, CoQ10 improved endothelial dysfunction in the mesenteric arteries. These findings suggest that the antioxidant properties of CoQ10 can be effective for ameliorating cardiovascular risk in MetS.

• 社団法人 日本薬理学会の論文
• 2008-06-20

著者

• KUNITOMO Masaru

  School of Pharmaceutical Sciences, Mukogawa Women's University

• Kunimoto M

  Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ

• Kunitomo Masaru

  京都大学 医学研究科糖尿病･栄養内科学

• Yamaguchi Yu

  Dep. Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's Univ. Jpn

• YAMAGUCHI Yu

  School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University

• KAGOTA Satomi

  School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University

• OTSUBO Kazumasa

  Fine Chemicals Division, Asahi Kasei Pharma Corporation

• Yamaguchi Yu

  School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University

• Kunitomo Masaru

  School Of Pharmaceutical Sciences Mukogawa Women's University

• Kunitomo Masaru

  Department Of Pharmacology Shizuoka College Of Pharmaceutical Science

• Otsubo Kazumasa

  Fine Chemicals Division Asahi Kasei Pharma Corporation

• Kagota Satomi

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Kunitomo Masaru

  Dep. Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's Univ. Jpn

• Saito K

  School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University

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