Role of K^+ Channels in M_2 Muscarinic Receptor-Mediated Inhibition of Noradrenaline Release From the Rat Stomach
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概要
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Previously we reported the cholinergic M2 muscarinic receptor-mediated inhibition of noradrenaline release from the rat stomach (K. Yokotani, Y. Osumi, J Pharmacol Exp Ther. 1993;264:54–60). In the present study, we investigated the role of K+ channels in oxotremorine (a muscarinic receptor agonist)-induced inhibition of noradrenaline release using isolated, vascularly perfused rat stomach. The gastric postganglionic sympathetic nerves were electrically stimulated twice at 2.5 Hz for 1 min and test reagents were added during the second stimulation. The electrically evoked release of noradrenaline was augmented by tetraethylammonium and 4-aminopyridine (non-selective K+ channel blockers) and also by charybdotoxin (a blocker of big conductance Ca2+-activated K+ channel). On the other hand, apamin (a selective blocker of small conductance Ca2+-activated K+ channels) and glibenclamide (an ATP-activated K+ channel blocker) had no effect on the evoked noradrenaline release. Oxotremorine-induced inhibition of noradrenaline release was attenuated by tetraethylammonium and 4-aminopyridine, while the inhibition was not influenced by charybdotoxin, apamin, and glibenclamide. These results suggest that tetraethylammonium- and 4-aminopyridine-sensitive K+ channels (probably voltage-activated K+ channels) are involved in the muscarinic receptor-mediated inhibition of noradrenaline release from the rat stomach.
- 社団法人 日本薬理学会の論文
- 2004-11-20
著者
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Nakamura Katsuya
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Nakamura K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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YAMAGUCHI NAOKO
Department of Medicine, Institute of Gastroenterology, School of Medicine, Tokyo Women's Medical Uni
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Shimizu Takahiro
Department Of Clinical Pharmacology Kyoto Pharmaceutical University
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YOKOTANI Kunihiko
Department of Pharmacology, School of Medicine, Kochi University
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Yokotani K
Kochi Medical School Kochi Jpn
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Yokotani Kunihiko
Department Of Pharmacology Kochi Medical School
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OKADA Shoshiro
Department of Pharmacology, Kochi Medical School
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NAKAMURA Kumiko
Department of Pharmacology, Kochi Medical School
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Nakamura Kazufumi
Faculty Of Pharmaceutical Sciences Kyushu University
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Shimizu Takahiro
Department Of Cell Physiology National Institute For Physiological Sciences
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Okada S
Department Of Pharmacology Kochi Medical School
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Yamaguchi Naoko
Department Of Medicine Institute Of Gastroenterology School Of Medicine Tokyo Women's Medical U
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Nakamura K
Department Of Physiology Ii Iwate Medical University School Of Medicine
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Nakamura Kumiko
Department Of Anesthesia And Intensive Care Medicine Yamaguchi Grand Medical Center
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Yokotani K
Department Of Pharmacology Kochi Medical School
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Shimizu T
Department Of Neuropharmacology Program Of Neural Integration Graduate School Of Medicine Kochi Univ
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YOKOTANI Keiko
Department of Neuropharmacology, Program of Neural Integration, Graduate School of Medicine, Kochi U
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Yamaguchi Naoko
Department Of Applied Chemistry Graduate School Of Engineering Osaka Prefecture University
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Yamaguchi Naoko
Department Of Neuropharmacology Program Of Neural Integration Graduate School Of Medicine Kochi Univ
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Yokotani Kunihiko
Department of Neuropharmacology, Program of Neural Integration, Graduate School of Medicine, Kochi University
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Okada Shoshiro
Department of Neuropharmacology, Program of Neural Integration, Graduate School of Medicine, Kochi University
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