Protective Effect of Basic Fibroblast Growth Factor Against Myocyte Death and Arrhythmias in Acute Myocardial Infarction in Rats

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概要

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• The present study in rats investigated whether basic fibroblast growth factor (bFGF) plays an important role in cardioprotection against myocardial cell death and arrhythmias in acute myocardial infarction (AMI). After ligating the left coronary artery in 62 Wistar rats, 20μg of human recombinant bFGF was injected into the infarcted myocardium in 33 rats (group F), while saline was used for 29 control rats (group C). The development of ventricular t achyarrhythmias was assessed during the first 30 min of ischemia. After 24h occlusion, the hearts of the surviving rats (group F : n=13, group C : n=10) were excised to assess minimum infarct wall thickness and infarct size, determine the number of TUNEL-positive cardiomyocytes and to analyze Bcl-2 and Bax expression by immunohistochemical staining and Western blotting. The incidence of ventricular tachycardia was higher in group C than in group F (p<0.05). The thinning ratio was higher in group F than in group C (p<0.05). There were fewer TUNEL-positive cardiomyocytes in the infarct border area in group F than in group C (p<.0001). Western blot analysis showed greater expression of Bcl-2 in group F than in group C (p<0.05), but similar expression of Bax in the 2 groups. Ln conclusion, intramyocardial administration of bFGF prevented ischemia-induced myocardial cell death and qrrythmias. (Cire J 2003 ; 67 : 334-339)

• 社団法人日本循環器学会の論文
• 2003-03-20

著者

• WATANABE GO

  Department of General and Cardiothoracic Surgery, Kanazawa University School of Medicine

• TANAKA Yoko

  Department of Pediatrics, Gifu University School of Medicine

• Nagamine Hiroshi

  department of Surgery (I), Kanazawa University School of Medicine

• Nishida Satoru

  department of Surgery (I), Kanazawa University School of Medicine

• Nishida Satoru

  Division Of Cardiac Surgery Tokyo Medical University

• Watanabe Go

  Department Of Applied Physics Graduate School Of Science And Engineering Waseda University

• Watanabe Go

  Department Of Thoracic & Cardiovascular Surgery Kanazawa University Hospital

• WATANABE Go

  Division of Cardiac Surgery, Tokyo Medical University

• Nagamine Hiroshi

  Department Of Surgery(i) Kanazawa University School Of Medicine

• Nagamine Hiroshi

  Department Of General And Cardiothoracic Surgery Kanazawa University Graduate School Of Medicical Sc

• Watanabe Go

  Department Of General And Cardiothoracic Surgery Kanazawa University Hospital

• Tanaka Yoko

  Department Of Applied Science For Electronics And Materials Graduate School Of Engineering Sciences

• Watanabe Go

  Department Of Surgery Kanazawa University Hospital

• Watanabe Go

  Division Of Cardiac Surgery Tokyo Medical University

• Tanaka Yoko

  Department Of Surgery(i) Kanazawa University School Of Medicine

• Tanaka Yoko

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

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