PROTEIN BINDING EFFECTS ON SALIVARY EXCRETION OF PHENOBARBITAL IN DOGS
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概要
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The salivary excretion of phenobarbital was investigated by collecting parotid saliva (Pr) and mandibular-sublingual saliva (MS) separately after intravenous administration in beagle dogs. (1) The alterations in the proportions of saliva secreted by the different glands were produced by salivation stimulants such as citric acid, ascorbic acid, sodium chloride and sodium glutamate. (2) The phenobarbital concentrations in both Pr and MS were lower than those in plasma. The drug concentrations in MS were significantly lower than in Pr with stimulus of 10% citric acid or 15% sodium chloride (p<0.05). There was a significant correlation between phenobarbital concentration in each saliva and plasma specimen (p<0.05). (3) The stimulation with 10% citric acid produced higher saliva/plasma drug concentration ratios (S/P ratios : 0.923±0.175 for Pr, 0.633±0.073 for MS) than that with 15% sodium chloride (S/P ratios : 0.597±0.071 for Pr, 0.509±0.067 for MS). (4) The S/P ratios were hardly influenced by salivary flow rates, at least under the experimental conditions examined in this study. (5) The increased S/P ratios were observed with higher salivary pH and then the equation of Matin et al. seemed to hold for the average values of salivary pH and S/P ratio. (6) The stimulation with 10% citric acid produced higher protein concentration in saliva and higher S/P ratio than that with 15% sodium chloride following alternate stimulations in the same dog.
- 公益社団法人日本薬学会の論文
著者
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OZEKI Shoji
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Nagoya City University
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Ozeki Shoji
Faculty Of Pharmaceutical Sciences Nagoya City University
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Iwamoto Kikuo
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:(present Ad
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Watanabe J
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Watanabe Jun
Department Of Anatomy & Cell Science Kansai Medical University
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Hayashi Yayoi
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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NAKASE YASUKO
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Nagoya City University
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URASAKI YOSHIMI
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Nagoya City University
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Nakase Yasuko
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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Urasaki Yoshimi
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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