EXCRETION OF INDOMETHACIN INTO SALIVA FOLLOWING INTRAVENOUS ADMINISTRATION TO DOGS
スポンサーリンク
概要
- 論文の詳細を見る
Parotid saliva (Pr) and mandibular-sublingual saliva (MS) were collected separately by means of permanent fistulae in order to investigate the excretion of indomethacin in saliva of dogs receiving a single intravenous dose of 20 mg/kg. Drops of citric acid solution were placed on the tongue to stimulate salivary secretion. The concentrations of indomethacin both in saliva and plasma declined biexponentially with time. There was a good linear relationship between the drug concentration in each saliva and plasma. The Pr and MS levels were 7.4% and 4.4% of the plasma levels, respectively. Indomethacin concentrations in Pr were significantly higher than in MS (p < 0.05). The roles of salivary pH and salivary protein binding were discussed in respect to the mechanism of salivary excretion of the drug.
- 公益社団法人日本薬学会の論文
著者
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OZEKI Shoji
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Nagoya City University
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Ozeki Shoji
Faculty Of Pharmaceutical Sciences Nagoya City University
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Iwamoto Kikuo
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:(present Ad
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Watanabe J
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Watanabe Jun
Department Of Anatomy & Cell Science Kansai Medical University
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NAKASE YASUKO
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Nagoya City University
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URASAKI YOSHIMI
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Nagoya City University
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UEDA HIDEMI
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Nagoya City University
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Nakase Yasuko
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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Ueda Hidemi
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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Urasaki Yoshimi
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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