A Minor Possibility of Pharmacokinetic Interaction between Enoxacin and Fenbufen in Rats
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概要
- 論文の詳細を見る
In order to clarify the possibility of pharmacokinetic interaction between quinolone and fenbufen, the plasma concentration-time profiles and serum protein binding of enoxacin, fenbufen and its active metabolite, felbinac, were investigated in rats. The rats were administered an intravenous dose of enoxacin (5 mg/kg) and fenbufen (10 mg/kg) alone or concomitantly. Coadministration with fenbufen tended to prolong the plasma elimination half-life of enoxacin by about 20%, whereas it showed no effect on the area under plasma concentration-time curve, total body clearance or distribution volume of enoxacin. The extent of enoxacin binding to rat serum tended to be slightly reduced by fenbufen in vivo and in vitro. Plasma concentration-time curves, pharmacokinetic parameters and serum protein binding of fenbufen and felbinac were not affected at all by the coadministration with enoxacin. These aspects suggest that there may be only a minor possibility of the pharmacokinetic interaction between enoxacin and fenbufen.
- 公益社団法人日本薬学会の論文
著者
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KATAGIRI Yoshihiro
Department of Pharmacy, Gifu University Hospital
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ICHIKAWA Nobuhiro
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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Ichikawa N
Department Of Pharmacy Shimane Medical University Hospital
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Ichikawa Nobuhiro
Department Of Hospital Pharmacy Nagasaki University Hospital Of Medicine And Dentistry
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Ichikawa Nobuhiro
島根医科大学附属病院 薬剤
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Katagiri Yoshihlro
Hokkaido Institute Of Pharmaceutical Sciences
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Katagiri Y
Hokkaido Institute Of Pharmaceutical Sciences
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NAORA KOHJI
Department of Pharmacy, Shimane Medical University Hospital
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IWAMOTO KIKUO
Department of Pharmacy, Shimane Medical University Hospital
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HAYASHIBARA MASAKAZU
Department of Pharmacy, Tottori University Hospital
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Naora K
Department Of Pharmacy Shimane University Hospital
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Naora Kohji
Department Of Pharmacy Shimane Medical University Hospital
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Iwamoto Kikuo
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:(present Ad
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Iwamoto K
Department Of Pharmacy Shimane University Hospital
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Iwamoto Kikuo
Department Of Pharmacy Shimane University Hospital
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Katagiri Yoshihiro
Department Of Biochemistry Gifu Pharmaceutical University
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Hayashibara M
Department Of Hospital Pharmacy Tottori University School Of Medicine
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HAYASHIBARA MASAKAZU
Department of Hospital Pharmacy, Tottori University School of Medicine
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Katagiri Yoshihiro
Deparhnent of Pharmacy Gifu University Hospital
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