Stability and Clinical Application of Tetracaine-Glycerin Injection for Nerve Blocks

概要

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Anhydrous tetracaine-glycerin injection was prepared for the diagnostic block of cancer pain. In addition to this preparation, hydrous tetracaine-glycerine injection was prepared for the treatment of herpetic pain or postherpetic neuralgia. The stability of these preparations was investigated under various sterilization and storage conditions. The clinical availability was also evaluated. Tetracaine in these preparations was completely stable under autoclaving and the subsequent storage at room temperature on exposure to light for 8 weeks. Anhydrous preparation was found to be useful as an agent for diagnostic block of cancer pain in all of 13 patients. All of 10 patients with herpetic pain gained a satisfactory relief of the pain following injection of the anhydrous or hydrous preparation, whereas the patients with postherpetic neuralgia gained no complete but temporary relief of pain.
日本医療薬学会の論文
1988-10-20