Pharmacological Properties of Traditional Medicines 23.Searching for Active Compounds in the Blood and Bile of Rats after Oral Administrations of Extracts of Sansohnin(酸棗仁)
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概要
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We made a trial of searching for the bioactive substances from Sandohnin(酸棗仁). The blood and bile of rats after the oral administration of extracts of Sansohnin were analyzed by three-dimensional high-performance liquid chromatography (3D-HPLC). In blood, spinosin and feruloyl spinosin were found after the oral administration of a butanol extract of Sansohnin. In bile, spinosin and feruloyl spinosin were also identified after the oral administration of a water extract of Sansohnin. Spinosin and feruloyl spinosin induced the prolongation of hexobarbital sleeping time in mice at doses of 50 and 100 mg/kg, respectively. We concluded that spinosin and feruloyl spinosin were the bioactive constituents of Sansohnin. It was assumed that spinosin and feruloyl spinosin circulated through the intestine and liver, therefore, these results will provide support for the sedative and hypnotic use of this crude drug in Oriental medicine.
- 公益社団法人日本薬学会の論文
- 1997-11-15
著者
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Saito K
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Kano Y
Hokkaido Coll. Pharmacy Otaru Jpn
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Katagiri Yoshihlro
Hokkaido Institute Of Pharmaceutical Sciences
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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SAITO Ken-ichi
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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Katagiri Y
Hokkaido Institute Of Pharmaceutical Sciences
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KAWASHIMA Keiko
Department of Kampo Medicinal Science, Hokkaido Pharmacutical University
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斉藤 謙一
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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Ozaki T
Pippu Clinic
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川嶋 恵子
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Shinozaki Kazuo
Riken Kanagawa Jpn
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Yamada Akiyoshi
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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OBARA Shin-ichi
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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OZAKI Takashi
Pippu Clinic
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Obara Shin-ichi
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Yamada Akiyoshi
Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University
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Kano Yoshihiro
Department Of Gastroenterological Surgery Osaka University Graduate School Of Medicine
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