Beta Ray-induced Scission of DNA in Tritiated Water and Protection by a Green Tea Percolate and (-)-Epigallocatechin Gallate

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概要

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• The β-ray induced scission of puC18 plasmid DNA from E. coli in tritiated water was examined in the presence or absence of a green tea percolate (TP) and the main constituent, (-)-epigallocatechin gallate (EGCg). An analysis of the ratio of the original closed-circular to the open-circular form of DNA, which was formed by the strand scission of DNA, revealed that TP and EGCg showed a protective effect on DNA scission depending on their concentrations. A new technique, named solid state spin trapping, was applied to examine this scavenging ability toward the hydroxyl (OH) radical generated in tritiated water. The result was kinetically analyzed to reveal that TP and EGCg showed the scavenging effect, suggesting that the protective effect on DNA scission was attributable to the scavenging effect on the OH radical.

• 1997-09-23

著者

• Saito K

  Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy

• SAITO Keiko

  Graduate School of Science and Technology, University of Chiba

• 斉藤 謙一

  Department Of Physiology And Anatomy Nihon University College Of Pharmacy

• YOSHIOKA Hisashi

  Graduate School of Nutritional and Environmental Sciences, University of Shizuoka

• YOSHIOKA Hisashi

  Institute for Environmental Sciences, University of Shizuoka

• Yoshioka H

  Univ. Shizuoka Shizuoka Jpn

• YOSHIOKA Hiroe

  Radiochemical Research Laboratory, Faculty of Science, Shizuoka University

• Shinozaki Kazuo

  Riken Kanagawa Jpn

• KUROSAKI Hiromu

  Radiochemistly Research Laboratory, Shizuoka University

• YOSHINAGA Kouichi

  Department of Chemistry, Faculty of Science, Shizuoka University

• Yoshinaga K

  Shizuoka Univ. Shizuoka‐shi Jpn

• Saito Keiko

  Graduate School Of Science And Technology University Of Chiba

• Kurosaki H

  Radiochemistly Research Laboratory Shizuoka University

• Yoshioka Hisashi

  Institute For Environmental Science University Of Shizuoka

• Yoshioka Hisashi

  Graduate School Of Nutritional And Environmental Sciences And School Of Pharmaceutical Sciences Univ

• Saito Keiko

  Graduate School of Nutritional and Environmental Sciences, University of Shizuoka

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