Salivary Excretion of Mexiletine after Bolus Intravenous Administration in Analbuminemic Rats
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the effect of plasma albumin on the salivary excretion of mexiletine, we have investigated the kinetics of and correlation between plasma and saliva levels following bolus intravenous administration (5 mg/kg) in male Sprague-Dawley rats (analbuminemic and normal). Parotid and mandibular saliva was collected separately by stimulating salivation with constant rate infusion of pilocarpine (50 μg/kg/min). In both rats, the mexiletine levels in plasma, parotid and mandibular saliva declined biexponentially with time in almost parallel fashion. Although the mexiletine levels in both types of saliva were lower than that in plasma ( p < 0.05 or 0.01), the drug level in parotid saliva was always higher than that in mandibular saliva in both groups ( p < 0.05 or 0.01). Furthermore, in both rats, significant correlations were observed when all data relating mexiletine concentration in plasma and saliva were included ( p < 0.001). The saliva to plasma drug concentration ratios (S/P ratios) for both saliva in analbuminemic rats (0.814 ± 0.162 for parotid saliva, 0.367 ± 0.074 for mandibular saliva) were higher than those in normal rats (0.727 ± 0.110 for parotid saliva, 0.197 ± 0.061 for mandibular saliva) (p < 0.01). These changes in the S/P ratios between both groups could not be explained by the pH for either parotid or mandibular saliva. In contrast, the slight increase in the unbound fraction of the drug in analbuminemic rats, though it was not significant from the unbound fraction in normal rats, tended to be consistent with the difference in the S/P ratios for both salivary glands. These aspects suggest the possibility that the extent of salivary excretion of mexiletine may be influenced by the albumin concentration and dependent on the unbound fraction in plasma.
- 日本医療薬学会の論文
- 1994-03-20
著者
-
TAKAHASHI Masakazu
Department of Pathology, Sasaki Institute
-
NAGASAKO SADAO
Department of Pharmacy, Shimane Medical University Hospital
-
IWAMOTO KIKUO
Department of Pharmacy, Shimane Medical University Hospital
-
HAYASHIBARA MASAKAZU
Department of Pharmacy, Tottori University Hospital
-
Nagasako Sadao
Department Of Pharmacy Shimane Medical University
-
Nagasako Sadao
Department Of Pharmacy Shimane Medical University Hospital
-
NAGASE Sumi
Department of Chemistry, Sasaki Institute
-
Nagase Sumi
Department Of Chemistry Sasaki Institute
-
Iwamoto Kikuo
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:(present Ad
-
Iwamoto K
Department Of Pharmacy Shimane University Hospital
-
Takahashi Masakazu
Department Of Microbiology Niigata College Of Pharmacy
-
Iwamoto Kikuo
Department Of Pharmacy Shimane University Hospital
-
Takahashi M
National Agricultural Res. Center For Kyushu Okinawa Region Kumamoto Jpn
-
Hayashibara M
Department Of Hospital Pharmacy Tottori University School Of Medicine
-
Takahashi Masakazu
Department Of Food Science And Technology Faculty Of Agriculture Kyoto University
-
Takahashi Masakazu
Department Of Bioscience Faculty Of Biotechnology Fukui Prefectural University
-
HAYASHIBARA MASAKAZU
Department of Hospital Pharmacy, Tottori University School of Medicine
関連論文
- α-Naphthylisothiocyanate Induces Intrahepatic Bile Duct with Greater Proliferation in Female Rats than in Males
- Methylation of neutral endopeptidase 24.11 promoter in rat hepatocellular carcinoma
- α-Smooth Muscle Actin-positive Stromal Cells Reactive to Estrogens Surround Endometrial Glands in Rats but not Mice
- Carcinogenic risks in the high-risk groups (SYMPOSIUM3: RECENT TOPICS ON THE RISK ASSESSMENT OF CHEMICAL CARCINOGENS) (Proceedings of the 30th Annual Meeting)
- The Role of Trehalose in Lipid Mobilization of Locusta migratoria : Effects of a Trehalase Inhibitor, Validoxylamine A, on Flight Activity and Hemolymph Trehalose and Lipid Concentrations
- Lethal Activity of a Trehalase Inhibitor, Validoxylamine A, and its Influence on the Blood Sugar Level in Bombyx mori(Lepidoptera:Bombycidae)
- THYROID PROLIFERATIVE LESIONS INDUCED BY ANTI-THYROID DRUGS IN RATS ARE NOT ALWAYS ACCOMPANIED BY SUSTAINED INCREASES IN SERUM TSH
- TIME COURSE OBSERVATION OF THYROID PROLIFERATIVE LESIONS AND SERUM LEVELS OF RELATED HORMONES IN RATS TREATED WITH KOJIC ACID AFTER DHPN INITIATION
- "P-41 A Morphometric study on the time course change of thyrotroph hypertrophy in the pituitary of rats treated with a goitrogen.
- Metabolic Degradation of [6]-Gingerol in Rat Jejunal Mucosa
- In Situ Jejunal Absorption of [6]-Gingerol in Rats
- Effect of Absorption Enhancers on the Permeation of Morphine in the Isolated Rectum of Rabbit
- A Minor Possibility of Pharmacokinetic Interaction between Enoxacin and Fenbufen in Rats
- Comparison of Saliva Stimulation Methods for Noninvasive Therapeutic Drug Monitoring by Using Saliva Samples
- A Minor Possibility of Pharmacokinetic Interaction between Norfloxacin and Fenbufen in Rats
- Simplified Procedures for the Simultaneous Determination of Enoxacin, Fenbufen and Felbinac in Rat Plasma by High-performance Liquid Chromatography
- Stability and Clinical Application of Tetracaine-Glycerin Injection for Nerve Blocks
- BLEOMYCIN-LIPIODOL SUSPENSION FOR INTRALYMPHATIC ADMINISTRATION IN ESOPHAGEAL CANCER
- Fate of Orally Administered ^15N-LabeIed Polyamines in Rats Bearing Solid Tumors
- Increases in Serum, Brain and Cerebrospinal Fluid Levels of Nalidixic Acid by Coadministration with Fenbufen in Rats
- Epidemiological Survey of Orientia tsutsugamushi Distribution in Field Rodents in Saitama Prefecture, Japan, and Discovery of a New Type
- Sebaceous Gland Metaplasia in a Mammary Fibroadenoma Developing in a Female Donryu Rat
- Uterine Adenocarcinoma in N-Ethyl-N'-nitro-N-nitrosoguanidine-treated Rats with High-dose Exposure to p-tert-Octylphenol during Adulthood
- High Yield Selective Induction of Uterine Endometrial Adenocarcinomas in CD-1 Mice by N-Ethyl-N'-nitro-N-nitrosoguanidine Combined with 17β-Estradiol
- in situ雑種法により決定した正常および無アルブミンラットにおけるアルブミン遺伝子の染色体上の位置〔英文〕
- The Production of Recombinant APRP, an Alkaline Protease Derived from Bacillus pumilus TYO-67, by In Vitro Refolding of Pro-enzyme Fixed on a Solid Surface
- Improved Autoprocessing Efficiency of Mutant Subtilisins E with Altered Specificity by Engineering of the Pro-Region^1
- Cryoprotective Effect of the Serine-Rich Repetitive Sequence in Silk Protein Sericin^1
- Role of Sortase in Biofilm Formation of Streptococcus mutans
- The Cytolethal Distending Toxin of Actinobacillus actinomycetemcomitans Activates p53-dependent DNA Damage Checkpoint Pathways in Normal Human Fibroblasts
- Difference of Lectin Receptors Between the Free Cell Type and Island Forming Cell Type of Rat Ascites Hepatoma Cells
- Effect of a Trehalase Inhibitor, Validoxylamine A, on Oocyte Development and Ootheca Formation in Periplaneta americana (Blattodea, Blattidae)
- Salivary Excretion of Mexiletine after Bolus Intravenous Administration in Analbuminemic Rats
- GLAND SPECIFIC DIFFERENCE IN SALIVARY EXCRETION OF UREA BETWEEN MANDIBULAR AND PAROTID SALIVARY GRANDS IN DOGS
- ROLE OF MANDIBULAR STRIATED DUCT IN SALIVARY EXCRETION OF UREA IN DOGS
- SALIVARY EXCRETION OF UREA IN DOGS
- Transepithelial Permeation of Tolbutamide across the Human Intestinal Cell Line, Caco-2
- Comparative Study on Salivary Distribution of Fluoroquinolones in Rats
- Changes in the Dissolution of Tolbutamide by a Traditional Chinese Medicine, Sho-saiko-to(Xiao Chaihu Tang)
- Effects of Sho-saiko-to(Xiao Chai Hu Tang), a Chinese Traditional Medicine, on the Gastric Function and Absorption of Tolbutamide in Rats
- Study on Residual Organic Solvent and Physicochemical Characteristics of Polylactic Acid Microspheres Containing Carmofur
- Solubilization, Purification and Properties of Hexose 6-Phosphate Dehydrogenase from Guinea Pig Liver Microsomes
- DISPOSITION OF SALICYLIC ACID IN ANALBUMINEMIC RATS
- EFFECTS OF URETHANE ANESTHESIA AND AGE ON ORGAN BLOOD FLOW IN RATS MEASURED BY HYDROGEN GAS CLEARANCE METHOD
- Complement C3a Agonist Peptides Derived From Proteins
- THE CHANGE OF DISPOSITION KINETICS FOR SOME WATERSOLUBLE COMPOUNDS ACCOMPANIED BY GROWTH IN MICE
- ABSORPTION, DISTRIBUTION AND ELIMINATION OF CREATININE AND UREA IN HYPERTHYROID MICE
- DISPOSITION OF CREATININE AND UREA IN BILATERALLY NEPHRECTOMIZED RATS
- DISTRIBUTION OF CREATININE FOLLOWING INTRAVENOUS AND ORAL ADMINISTRATION TO RATS
- Salivary Excretion of 5-Fluorouracil. II. Fluctuation of Saliva/Plasma Concentration Ratio and Salivary Clearance during a Constant Rate Intravenous Infusion in Beagle Dogs
- DOSE-DEPENDENT DISPOSITION OF FRACTIONATED ^3H-HEPARIN IN RATS
- DISPOSITION OF FRACTIONATED ^3H-HEPARIN IN RATS
- DISPOSITION OF TRITIUM-LABELLED HEPARIN IN RATS
- PROTEIN BINDING EFFECTS ON SALIVARY EXCRETION OF PHENOBARBITAL IN DOGS
- EXCRETION OF INDOMETHACIN INTO SALIVA FOLLOWING INTRAVENOUS ADMINISTRATION TO DOGS
- 1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a Superoxide Generation Inhibitor from Perilla frutescens var. crispa
- Spontaneous Tumors in the Uterus, Testis and Other Organs of F_1 Hybrids between Donryu and F344 Rats
- A Spontaneous Rat Ovarian Cystoadenocarcinoma with Papillary Growth to the Serosa.
- Utilization of Salivary Level Monitoring of Mexiletine in the Therapy of Arrhythmic Patients.
- Uterine Carcinogenesis by Chemicals/Hormones in Rodents.