Effect of a Trehalase Inhibitor, Validoxylamine A, on Oocyte Development and Ootheca Formation in Periplaneta americana (Blattodea, Blattidae)
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概要
- 論文の詳細を見る
Injection of a specific trehalase inhibitor, validoxylamine A(VAA), suppressed oocyte development in the American cockroach, Periplaneta americana. Ootheca formation was also affected by the same treatment. Inhibition of trehalases of ovaries and thoracic muscles in P. americana in vitro by VAA was very strong; I_<50> values were 5.0×10^<-9> M and 1.4×10^<-8> M, respectively. When the inhibition of trehalase activity was measured after injection of VAA(5 and 50 μg/insect) into cockroaches, more than 90% of the activity in the ovaries was inhibited. The high level of inhibition lasted 2 weeks at the higher dosage, but recovery activity was observed in the second week following the injection of the lower dosage. VAA injection also inhibited the muscular trehalase but to a lesser degree than the ovarian trehalase. Enhancement of haemolymph trehalose concentration and the maintenance of its higher level after the injection of VAA suggested strong inhibition of trehalase in various tissues of the cockroach. It is speculated that the uptake of materials required for oocyte development as well as the energy supply was prevented through the inhibition of trehalase.
- 日本応用動物昆虫学会の論文
- 1997-05-25
著者
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TAKAHASHI Masakazu
Department of Pathology, Sasaki Institute
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Mihara Minoru
Department Of Medical Entomology National Institute Of Health
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Mihara Minoru
Department Of Medical Entomology The National Institute Of Health
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NISHINA Masami
Department of Medical Zoology, Saitama Medical School
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MATSUSHITA Kazuhiro
Department of Medical Zoology, Saitama Medical School
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KONO Yoshiaki
Department of Medical Entomology, National Institute of Infectious Diseases
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Kono Y
Mitsubishi Heavy Industries Ltd. Kobe Shipyard & Machinery Works
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Takahashi M
Kubota Corp Ibaraki Jpn
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Kono Y
Graduate School Of Life And Environmental Sciences University Of Tsukuba
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Nishina Masami
Department Of Immunology Saitama Medical School
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Takahashi Masakazu
Department Of Microbiology Niigata College Of Pharmacy
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Matsushita Kazuhiro
Laboratory Of Applied Entomology And Zoology Institute Of Agriculture And Forestry University Of Tsu
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KAMEDA Yukihiko
School of Pharmacy, Hokuriku University
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MATSUSHITA Kazuhiro
JEOL Ltd.
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Kameda Yukihiko
School Of Pharmacy Hokuriku University
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Kono Yoshiaki
Department Of Educational Psychology Tokyo Gakugei University
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Takahashi Masakazu
Department Of Food Science And Technology Faculty Of Agriculture Kyoto University
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Takahashi Masakazu
Department Of Bioscience Faculty Of Biotechnology Fukui Prefectural University
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MATSUSHITA Kazuhiro
Laboratory of Applied Entomology and Zoology, Institute of Agriculture and Forestry, University of Tsukuba
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