Difference of Lectin Receptors Between the Free Cell Type and Island Forming Cell Type of Rat Ascites Hepatoma Cells

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概要

• 論文の詳細を見る

• The cell surface glycoconjugates of various rat ascites hepatoma cell lines with different degrees of adhesiveness were compared, by binding assays, using ^<125>I-labelled lectins. Effects of neuraminidase, TPCK-trypsin and chondroitinase ABC treatment of the cells, on the number of lectin receptor sites were also studied. The TPCK-trypsin treatment caused a marked decrease in the number of peanut agglutinin receptor sites on the island forming and mixed cell types. The decrease of wheat germ agglutinin receptor sites and the increase of castor bean agglutinin receptor sites, after neuraminidase treatment, were larger on the free cell type. It is therefore possible that α-sialyl-β-D-galactosyl residues are abundant on the cell surface of this type, and that its low cell adhesiveness may be due to a electrostatic repulsion of negative charges of the sialic acid.

• お茶の水女子大学の論文

著者

• Matsumoto I

  お茶の水女子大学

• Matsumoto Isamu

  The Graduate School Of Humanities And Sciences Ochanomizu University

• MATSUMOTO Isamu

  Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University

• Seno N

  Department Of Chemistry Ochanomizu University

• Seno Nobuko

  Department Of Chemistry Faculty Of Science Ochanomizu University

• Matsumoto I

  Ochanomizu Univ. Tokyo

• Matsumoto Isamu

  Matsumoto Institute Of Life Science

• Matsumoto Isamu

  Division Of Human Genetics Medical Research Institute Kanazawa Medical University

• Matsumoto Isamu

  Department Of Chemistry Faculty Of Science Ochanomizu University

• Matsumoto Isamu

  Graduate School Of Humanities And Sciences Ochanomizu University

• NAGASE Sumi

  Department of Chemistry, Sasaki Institute

• Nagase Sumi

  Department Of Chemistry Sasaki Institute

• Kitagaki Haruko

  Department of Chemistry, Faculty of Science, Ochanomizu University

• Kitagaki Haruko

  Department Of Chemistry Faculty Of Science Ochanomizu University

• MATSUMOTO ISAMU

  Department of Biochemistry, Kurume University School of Medicine

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