Regional Distribution of Mucopolysaccharides in the Pig Kidney

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Mucopolysaccharides were isolated from the cortex and medulla of pig kidney, and characterized by chemical analysis, electrophoresis and enzymic digestion. The mucopolysaccharides in the cortex were found to be mainly heparan sulfate and dermatan sulfate, with trace amounts of hyaluronic acid and chondroitin sulfate A. In the medulla, heparan sulfate was also the major mucopolysaccharide, with dermatan sulfate and hyaluronic acid, and a trace of chondroitin sulfate A. This mucopolysaccharide pattern of the medulla was quite different from those of other animals. Three heparan sulfate fractions obtained from both the cortex and medulla by Dowex 1 chromatography showed different contents of sulfate, but there was practically no difference in the amounts of N-sulfated hexosamine. After alkaline reduction, it was proved that the heparan sulfates are linked to peptides through O-glycosidic bonds between xylose and serine, as in the chondroitin sulfates.
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