ANALYSIS OF HYPOTENSIVE MECHANISMS OF PINDOLOL, A β-ADRENOCEPTOR BLOCKING DRUGS IN RATS

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The hypotensive mechanisms of pindolol in anesthetized and conscious rats were investigated. Pindolol caused a fall in blood pressure in anesthetized, conscious and spinal rats, though in conscious rats a higher dose of the drug was required to produce such a response. This hypotension with pindolol in anesthetized and conscious rats was markedly inhibited by pretreatment with the drug itself or other β-adrenoceptor blocking drugs. A similar phenomenon also occurred when isoproterenol was injected intravenously in anesthetized and conscious rats. The relationship between the hypotensive actions of four β-adrenoceptor blocking drugs in anesthetized rats and their intrinsic β-sympathomimetic actions in isolated catecholamine-depleted tracheal preparations was determined. Order of hypotensive potencies was the same as that of their intrinsic β-sympathomimetic action, namely, pindolol>carteolol>bufetolol≈propranolol (p<0.05). These results suggest that the hypotension with pindolol is mediated through a decrease in the peripheral vascular resistance due to an intrinsic β-sympathomimetic action of the drug.
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