Long Term Effects of Toki-shakuyaku-san on Brain Dopamine and Nerve Growth Factor in Olfactory-Bulb-Lesioned Mice
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概要
- 論文の詳細を見る
We used olfactory-bulb-lesioned mice induced by intranasal irrigation with zinc sulfate as a model of dementia, to investigate the effects of Toki-shakuyaku-san (TSS) on monoamines and nerve growth factor (NGF) in brain regions. TSS was given daily through the drinking water for either 1, 2, 3, 4 or 8 weeks from the day after olfactory lesion. The administration of TSS significantly suppressed the decrease of 3,4-dihydroxyphenyl acetic acid (DOPAC) and homovanillic acid (HVA) in olfactory bulb of olfactory-lesioned mice at 1 week, and tended to suppress the decrease of DOPAC and HVA during the experimental session. However, the administration of TSS had no influence on dopamine contents. NGF contents in the olfactory bulb were increased after the irrigation, and the value returned to the same level as the control at 8 weeks after. Although the NGF contents in the olfactory bulb of TSS-treated mice were immediately increased at 1 and 2 weeks, the value returned to normal level within 3 weeks. These findings indicate that oral administration of TSS prevents the reduction of dopamine metabolites, DOPAC and HVA, and immediately increased NGF contents in the olfactory bulb. This suggested that TSS treatment promotes the NGF contents in olfactory nerves and rescue the neurons from damage.
- 社団法人 日本薬理学会の論文
- 2001-06-01
著者
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CYONG Jong-Chol
Department of Medical History, Juntendo University School of Medicine
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Cyong Jong-chol
Department Of Bioregulation Function Graduate School Of Medicine The University Of Tokyo:medical His
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Song Q‐h
Univ. Tokyo Tokyo Jpn
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Song Qing-hua
東京大学 生体防御機能
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Song Qing-hua
Department Of Bioregulation Function Graduate School Of Medicine The University Of Tokyo
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Song Qing-hua
Department Of Bioregulatory Function Graduate School Of Medicine The University Of Tokyo
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Cyong J‐c
Juntendo Univ. Tokyo Jpn
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Toriizuka Kazuo
Oriental Medicine Res. Center Of The Kitasato Inst. Tokyo
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SONG Qing-Hua
The Research Division, Oriental Medicine Research Center, The Kitasato Institute
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TORIIZUKA Kazuo
The Research Division, Oriental Medicine Research Center, The Kitasato Institute
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JIN Guang-Bi
The Research Division, Oriental Medicine Research Center, The Kitasato Institute
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YABE Takeshi
The Research Division, Oriental Medicine Research Center, The Kitasato Institute
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Cyong Jong-chol
Department Of Bioregulatory Function Graduate School Of Medicine The University Of Tokyo
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Toriizuka K
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Cyong Jong-chol
Department Of Bioregulation Function Graduate School Of Medicine The University Of Tokyo
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Jin Guang-bi
The Research Division Oriental Medicine Research Center The Kitasato Institute
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Yabe Takeshi
The Research Division Oriental Medicine Research Center The Kitasato Institute
関連論文
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- Long Term Effects of Toki-shakuyaku-san on Brain Dopamine and Nerve Growth Factor in Olfactory-Bulb-Lesioned Mice
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