Components of Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) and changes in blood flow in the human central retinal artery
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概要
- 論文の詳細を見る
我々は,最新の超音波画像診断装置を用いて,八味地黄丸のエキス顆粒に,網膜中心動脈の血流増加作用を見出した。そこで,八味地黄丸の構成生薬とその作用の関連性について,煎じ薬を用いて検討を加えた。八味地黄丸の煎じ薬(八味地黄丸料)は,エキス顆粒と同様,網膜中心動脈の血流増加作用を示した。しかし,六味丸の煎じ薬(六味丸料)やエキス顆粒には,網膜中心動脈の血流増加作用は認められなかった。また,桂皮,附子各(一味)の煎じ薬の投与により,網膜中心動脈は,血管抵抗の減少を認めた。しかし,桂皮と附子を合わせた二味の煎じ薬や,六味丸に桂皮か附子を加えた(八味地黄丸から附子か桂皮を除いた)七味の煎じ薬では,かえってその作用は打ち消されてしまうようで,血流増加作用はみられなかった。八味地黄丸の血流増加作用は,六味丸,桂皮,附子すべてがそろって八味になることによって,はじめて現されるものと考えられた。
- 和漢医薬学会の論文
- 2002-06-20
著者
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YAMAMOTO KAZUHIKO
Department of Biochemistry, Kinki University
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Cyong Jong-chol
Department Of Bioregulation Function Graduate School Of Medicine The University Of Tokyo:medical His
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Cyong J‐c
Juntendo Univ. Tokyo Jpn
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ISOBE Hideyuki
Departments of Urology and Pathology, Juntendo University School of Medicine
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Cyong Jong-chol
Department Of Bioregulation Function Graduate School Of Medicine The University Of Tokyo
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Isobe Hideyuki
Department Of Bioregulatory Function Graduate School Of Medicine University Of Tokyo:department Of A
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Yamamoto Kazuhiko
Department Of Allergy And Rheumatology Graduate School Of Medicine The University Of Tokyo
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Yamamoto Kazuhiko
Department Of Allergy And Rheumatology Graduate School Of Medicine University Of Tokyo
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