Significance of Antigen-Specific T Cell Clones in Collagen Diseases: Analyses with a Novel T Cell Clonality Evaluation System
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概要
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The involvement of antigen-specific T cells in the pathogenesis of collagen diseases is still controversial. The final stages of collagen diseases are usually characterized by the dominance of inflammation. Therefore, antigen non-specific factors, such as inflammatory cytokines, probably play an important role in this process. On the other hand, the methods available to analyze the antigen-specific aspects of the immune response are still limited. Here we review our novel system of T cell clonality analysis based on the idea that activated antigen-specific T cells should form accumulating clones among the lymphocyte population. Using this method, dynamic changes of clonal accumulation of T cells could be evaluated during antigenic stimulation in vivo and in vitro. The significance of antigen-specific T cell clones in collagen diseases is discussed using data obtained from patients with rheumatoid arthritis and systemic lupus erythematosus.(Internal Medicine 36: 242-247, 1997)
著者
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Yamamoto Kazuhiko
Department Of Allergy And Rheumatology Graduate School Of Medicine The University Of Tokyo
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Yamamoto Kazuhiko
Department Of Clinical Immunology Medical Institute Of Bioregulation Kyushu University
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