Effect of Freeze-Thawing and Polyethylene Glycol (PEG) Lipid on Fusion and Fission of Phospholipid Vesicles
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概要
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The effect of freeze-thawing on the size of egg yolk phosphatidylcholine (EggPC) vesicles in the presence of 0-40mol% distearoylphosphatidylethanolamine-polyethylene glycol 2000 (DSPE-PEG) was studied. Mean diameters of the vesicles fell into a range of 80-150nm after 10 times freeze-thawing in spite of their original size. In the process of freeze-thawing, two opponent events, one is fission and the other is fusion, occurred at the same time. DSPE-PEG accelerated the fusion event.
- 公益社団法人日本薬学会の論文
- 2004-05-01
著者
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Ueno Masaharu
Faculty Of Phamaceutical Sciences Toyama Medical And Pharmaceutical University
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Sriwongsitanont S
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Sriwongsitanont Supaporn
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Ueno M
Fac. Of Pharmaceutical Sciences Univ. Of Toyama
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