Synthesis and Reaction of 1-Azabicyclo[3.1.0]hexane

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概要

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• The effective formation of 1-azabicyclo[3.1.0]hexane (5) by treatment of 2-(bromomethyl)pyrrolidine hydrobromide (4) with n-BuLi was established, with the reaction occurring by a rational reaction pathway via the open chain transition state 8 based on intermolecular Br···Li+ coordination (SN2 process). The reaction of 5 with electrophiles 13a—n gave the corresponding pyrrolidines 14a—n and piperidine 6, 15a—g, i—n. The selectivity of the products in this reaction appeared to be controlled by equilibrium.

• 社団法人 日本薬学会の論文

著者

• SHIRO Motoo

  Rigaku Corporation X-ray Research Laboratory

• Shiro Motoo

  Rigaku Corporation

• Hayashi Kazuhiko

  College of Pharmacy, Kinjo Gakuin University

• Kujime Eiko

  College of Pharmacy, Kinjo Gakuin University

• Katayama Hajime

  College of Pharmacy, Kinjo Gakuin University

• Sano Shigeki

  Graduate School of Pharmaceutical Sciences, The University of Tokushima

• Nagao Yoshimitsu

  Graduate School of Pharmaceutical Sciences, The University of Tokushima

• Sano Shigeki

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• Hayashi Kyoko

  Faculty Of Medicine Toyama Medical And Pharmaceutical University

• Nagao Yoshimitsu

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• Shiro Motoo

  Rigaku Co.

• Hayashi K

  Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama

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