Efficient Synthesis of Isothiocyanates Based on the Tandem Staudinger/aza-Wittig Reactions and Mechanistic Consideration of the Tandem Reactions

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概要

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• The tandem and stepwise Staudinger/aza-Wittig reactions of several azides were examined in detail. The tandem reaction method (Method I) exhibited superior results in the yield of the corresponding isothiocyanates bearing an electron-withdrawing group than the conventional stepwise method (Method II) which involves the sequential treatment of the azides with triphenylphosphine and then carbondisulfide. The mechanistic consideration for both reaction methods was proposed on the basis of the ^1H-NMR analyses.

• 公益社団法人日本薬学会の論文
• 2006-11-01

著者

• Nagao Yoshimitsu

  Graduate School of Pharmaceutical Sciences, The University of Tokushima

• KUMAGAI Toshio

  Medical Research Laboratories, Wyeth Lederle Japan, Ltd.

• 長尾 善光

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• 長尾 善光

  徳島大学薬学部

• Nagao Yoshimitsu

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• Nagao Y

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• Nagao Yoshimitsu

  Faculity Of Pharmaceutical Sciences The University Of Tokushima

• Tamai Satoshi

  Medical Research Laboratories Wyeth K.k.

• Kumagai Toshio

  Medical Research Laboratories Wyeth K.k.

• Isoda Takeshi

  Medical Research Laboratories Wyeth K.k.

• HAYASHI Kazuhiko

  Medical Research Laboratories, Wyeth K.K.

• Hayashi Kazuhiko

  Medical Research Laboratories Wyeth K.k.

• Tamai Satoshi

  Medical Research Laboratories

• Kumagai Toshio

  Medical Research Laboratories

• Isoda Takeshi

  Medical Research Laboratories

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