Expeditious Syntheses of Conjugated Allenyl Esters and Oxazoles through a Cascade Reaction of α-Alkynyl Malonates under Alkaline Conditions

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概要

• 論文の詳細を見る

• Diethyl α-alkynyl-α-methoxymalonates (2a-e) were smoothly hydrolyzed and then decarboxylated under alkaline conditions employing 1 N KOH in EtOH to give conjugated allenyl esters (6a-e) in high yields, and similar alkaline treatment of diethyl α-alkynyl-α-acetylaminomalonates (5a, b, d, e) furnished unexpectedly the oxazoles (7a, b, d, e) having three substituent groups in excellent yields.

• 公益社団法人日本薬学会の論文
• 2006-02-01

著者

• SHIRO Motoo

  Rigaku Corporation X-ray Research Laboratory

• Shiro Motoo

  Rigaku Corporation

• Shiro M

  Rigaku Corp. Tokyo

• Sano Shigeki

  Graduate School of Pharmaceutical Sciences, The University of Tokushima

• Nagao Yoshimitsu

  Graduate School of Pharmaceutical Sciences, The University of Tokushima

• 佐野 茂樹

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• 佐野 茂樹

  徳島大学薬学部

• Sano Shigeki

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• Lee Woo

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• 長尾 善光

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• Shimizu Hisashi

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• KIM Kweon

  Graduate School of Pharmaceutical Sciences, The University of Tokushima

• Kim Kweon

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• 長尾 善光

  徳島大学薬学部

• Nagao Yoshimitsu

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• Nagao Y

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• Nagao Yoshimitsu

  Faculity Of Pharmaceutical Sciences The University Of Tokushima

• Shiro M

  Rigaku Corporation

• Suzuki Mitsuko

  Institute For Chemical Research Kyoto University

• Masuoka S

  Takara Agri Co. Ltd.

• Shiro Motoo

  Rigaku Co.

• Shiro Motoo

  Shionogi Research Laboratry Shionogi & Co. Ltd.

• Mito S

  Institute For Chemical Research Kyoto University

• Lee Woo

  Graduate School Of Agricultural And Life Sciences The University Of Tokyo

• Shiro M

  Rigaku Corp. Akishima Jpn

• Lee WS

  Graduate School of Pharmaceutical Sciences, The University of Tokushima

• Nagao Y

  Graduate School of Pharmaceutical Sciences, The University of Tokushima

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