Synthesis and Antibacterial Activity of New 1β-Methylcarbapenems Having the Potential for Intramolecular Nonbonded S・・・O Interactions

スポンサーリンク

概要

• 論文の詳細を見る

• Mercaptoacetyliminothiadiazoline derivatives(19, 20)useful for the pendant moiety of 1β-methylcarbapenem antibiotics were efficiently synthesized. Acetyl derivative(18)of 20 was submitted to X-ray analysis, and a significant nonbonded S・・・O close contact was recognized in the crystallographic structure. New 1β-methylcarbapenems(5, 6)were synthesized by exploiting 19 and 20, and exhibited considerable antibacterial activities in vitro.

• 公益社団法人日本薬学会の論文
• 2001-12-01

著者

• SHIRO Motoo

  Rigaku Corporation X-ray Research Laboratory

• Shiro Motoo

  Rigaku Corporation

• Shiro M

  Rigaku Corp. Tokyo

• NAGAO Yoshimitsu

  Faculity of Pharmaceutical Sciences, The University of Tokushima

• SANO Shigeki

  Faculty of Pharmaceutical Sciences, The University of Tokushima

• 佐野 茂樹

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• 佐野 茂樹

  徳島大学薬学部

• 長尾 善光

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• 長尾 善光

  徳島大学薬学部

• IIMORI Hitoshi

  Faculty of Pharmaceutical Sciences, The University of Tokushima

• NAM Ki

  Faculty of Pharmaceutical Sciences, The University of Tokushima

• Nagao Y

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• Nagao Yoshimitsu

  Faculity Of Pharmaceutical Sciences The University Of Tokushima

• Nam Ki

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• Shiro M

  Rigaku Corporation

• Iimori Hitoshi

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• Suzuki Mitsuko

  Institute For Chemical Research Kyoto University

• Masuoka S

  Takara Agri Co. Ltd.

• Nagao Y

  Faculty Of Agriculture Utsumomiya University

• Shiro Motoo

  Rigaku Co.

• Shiro Motoo

  Shionogi Research Laboratry Shionogi & Co. Ltd.

• Mito S

  Institute For Chemical Research Kyoto University

• Shiro M

  Rigaku Corp. Akishima Jpn

• Sano S

  Faculty of Pharmaceutical Sciences, The University of Tokushima

• Iimori H

  Faculty of Pharmaceutical Sciences, The University of Tokushima

• Nam KH

  Faculty of Pharmaceutical Sciences, The University of Tokushima

関連論文

• Preparation of New Nitrogen-Bridged Heterocycles 67. Syntheses of α,α′-Bis[(thieno[3,4-b]indolizin-3-yl)thio]-o-, m-, and p-xylene Derivatives and Their Conformational Structures
• Structure and Stereochemistry of the Higher Bile Acid Isolated from Turtle Bile : (22S, 25R)-3α, 12α, 15α, 22-Tetrahydroxy-5β-cholestan-26-oic Acid
• An Alkoxide-Bridged Dinuclear Zinc(II) Hexaazacryptate : A Novel Phosphate Capture Molecule in Aqueous Solution
• RADIOSENSITIZING HYPOXIC CELLS WITH NEW 3-NITRO-1,2,4-TRIAZOLE DERIVATIVES IN VITRO AND IN VIVO
• Crystal Structure of Complex of Gallocatechin Gallate and Caffeine
• Synthesis and Reaction of 1-Azabicyclo[3.1.0]hexane
• Intramolecular Nonbonded S…N Interaction in Rabeprazole
• Synthesis of New Quinolone Antibiotics Utilizing Azetidine Derivatives Obtained from 1-Azabicyclo[1.1.0]butane
• Effects of Magnesium Salts and Amines on the Stereoselectivity in the Imine Aldol Reaction
• Mechanistic Considerations for the Consecutive Cyclization of 2,3-Dibromopropylamine Hydrobromide Giving a Strained Molecule, 1-Azabicyclo[1.1.0]butane
• Synthesis of New Chiral Sulfinyldiacetic Acid Derivatives and Attempt at Chemoselective Asymmetric Pummerer Reaction
• The budget of dissolved trace metals in Lake Biwa, Japan
• Enantioselective Construction of a 2,8-Dioxabicyclo[3.2.1]octane Ring System via [2,3]-Sigmatropic Rearrangement of Oxonium Ylide Using Chiral Dirhodium(II) Carboxylates
• Absolute Configuration of Migrastatin, a Novel 14-Membered Ring Macrolide
• Lactonamycin, a New Antimicrobial Antibiotic Produced by Streptomyces rishiriensis MJ773-88K4 II. Structure Determination
• Isolation from Streptomyces of a Novel Naphthoquinone Compound, Naphthablin, That Inhibits Abl Oncogene Functions
• Practical Synthesis of Chiral cis-Cyclohex-4-ene-1,2-dicarboxylic Acid Derivatives by Utilizing (4S)-Isopropyl-1,3-thiazolidine-2-thione
• 赤外線蛍光内視鏡の原理と臨床応用
• 2,5-Bis(1', 3'-dithiol-2'-ylidene)-1, 3, 4, 6-tetrathiapentalene and its Related Unsymmetrical Donors
• Preparation, Crystal Structure and Electrical Properties of 2-Cyclopentanylidene-1,3-dithiolo[4,5-d]tetrathiafulvalene Derivatives
• Methylthio Substituted 2,5-Bis(1',3'-dithiol-2'-ylidene)-1,3,4,6-tetrathiapentalene. A Bis-Fused Tetrathiafulvalene
• Diastereoselective Alkylation of Chiral Tin(II) Enolates onto Cyclic Acyl Iminium Ions. : Asymmetric Total Syuthesis of (-)-Supinidine.
• Highly Diastereoselective Alkylation of Chiral Tin(II) Enolates onto Cyclic Acyl Imines, An Efficient Asymmetric Synthesis of Bicyclic Alkaloids Bearing a Nitrogen Atom Ring Juncture.
• New General Asymmetric Synthesis of Versatile γ-Alkylated Butenolides and Its Application to Expeditious Synthesis of the Chiral Geissman-Waiss Lactones Useful for (+)-Retronecine Synthesis.
• 21世紀のメディシナルケミスト
• Differential Contribution of Metal Complexation and Dimerization to the Chemotherapeutic Potential of Bicyclen-Zn^_2 Complex against Human Immunodeficiency Virus
• A Versatile Macrocyclic [12]aneN_3 for Interconversion of Tetrahedral and Trigonal Bipyramidal Zinc(II) Complexes. Relevance to Four-【double half arrows】 Five-Coordinate Geometries of Zinc(II) in Carbonic Anhydrase
• Unprecedented Soliton Formation Mechanism in Quasi-One-Dimensional Chloro-Bridged Pt^-Pt^ Mixed-Valence Compound, {[Pt(en)_2][PtCl_2(en)_2]}_3(CuCl_4)_4・12H_2O
• Synthesis and some properties of phosphoimino-1-azaazulene derivatives
• Expeditious Syntheses of Conjugated Allenyl Esters and Oxazoles through a Cascade Reaction of α-Alkynyl Malonates under Alkaline Conditions
• Enzymatic Hydrolyses of the σ-Symmetric Dicarboxylic Diesters Bearning a Sulfinyl Group as the Prochiral Center
• P-33 α置換セリン誘導体の不斉合成を基盤とする(+)-ラクタシスチンの不斉全合成研究(ポスター発表の部)
• A New Convenient Synthesis of α-Pyrone and α-Pyridone Derivatives
• Expeditious Asymmetric Synthesis of Optically Pure δ-Lactones Bearing Consecutive Three Asymmetric Centers
• Axial Preference of Bulky Group- and Electron-Withdrawing Group-Substituted Oxygen Atom on the Chair-Type Cyclohexanone, Glutaric Anhydride, and Glutarimide.
• Synthesis, Structure, and Self-Oxidation of Alkynyl(phenyl)iodonium Periodates.
• A Facile Synthesis of Novel Chiral Phosphonoacetates Bearing a Stereogenic Phosphorus Atom
• A Facile Method for the Stereoselective Horner-Wadsworth-Emmons Reaction of Aryl Alkyl Ketones
• Synthesis and Antibacterial Activity of New 1β-Methylcarbapenems Having the Potential for Intramolecular Nonbonded S・・・O Interactions
• New Six- to Eight-Membered-Ring Formation Based on the Intramolecular Endo- Mode Ring Closure of Allenyl (Substituted Phenyl)alkyl Ketones
• Characterization of the Sulfonic Esters Adopting a Folded Conformation with Stacked Aromatic Moieties
• X-Ray Structure of [Be{B(pz)_4}_2] and [Be_3(OH)_3 {HB(pz)_3}_3]. Different Structures and Multiple-Point Bindings in Polypyrazolylboreate Complexes
• Characterization of suspended solids in Lake Biwa by measuring their elemental composition of Al, Si, P, S, K, Ca, Ti, Mn, and Fe
• Stereoselective Synthesis of Tetrasubstituted (Z)-Alkenes from Aryl Alkyl Ketones Utilizing the Horner-Wadsworth-Emmons Reaction
• Effects of the substances secreted from Closterium aciculare (Charophyceae, Chlorophyta) on the growth of freshwater phytoplankton under iron-deficient conditions
• Determination of Minor and Trace Elements in Biogenic Carbonate Minerals of Coccolithophores by High-Resolution Inductively Coupled Plasma Mass Spectrometry
• The possibility of regulating the species composition of marine phytoplankton using organically complexed iron
• A New Type of Inclusion Compounds Composed of a Charge-Transfer Complex between Tetrakis(phenylethynyl)ethene and 2,4,7-Trinitrofluorenone
• Preparation and Crystal Structure of a Parent l-Arylbenzo〔b〕thiophenium Triflate and Its Derivatives
• Porous Magnets Based on Copper-Octacyanotungsten Containing Noncoordinated Alcohol Molecules
• New Xenia Diterpenoids from a Soft Coral, Xenia Species
• Efficient Synthesis of Isothiocyanates Based on the Tandem Staudinger/aza-Wittig Reactions and Mechanistic Consideration of the Tandem Reactions
• A Practical and Facile Synthesis of Azetidine Derivatives for Oral Carbapenem, L-084
• Syntheses and Pharmacokinetic Studies of Prodrug Esters for the Development of Oral Carbapenem, L-084
• Synthesis, Structures, and Magnetic Properties ofDinuclear Nickel(II) Complexes ContainingN,N,N',N'-Tetrakis[(1-methyl-2-benzimidazolyl)methyl]-2-hydroxy-1,3-diaminopropane and a Thiocyanate Ion
• Facile synthesis of (2-Benzimidazolyl)-1-azaazulenes, (2-Benzothiazolyl)-1-azaazulenes, and related compounds and evaluation of their anticancer in vitro activity
• Facile synthesis of (2-benzimidazolyl)-1-azaazulenes, (2-benzothiazolyl)-1-azaazulenes, and related compouds and evaluation of their anticancer in vitro activity
• Synthesis of Aryl Conjugated (1-Azaazulenyl)acetylenes and Facile Synthesis of Thiophene Fused 1-Azaazulenes
• Dibridged Bis(Zn^-cyclen) : A Novel Host Molecule of Malonate Dianion in Aqueous Solution
• On the Mechanism of Stereoisomerization of Methyl Groups of 1,3-Diaxial[cis-3-Benzyloxy)cyclohexyl]chlorodimethylstannane.
• Self-Assemble of Chelator-Type Nucleic Acid Mimics into a Single-Stranded Zn^ Coordination Polymer
• Molecular Design and Crystal Structures of Chiral Macrotricyclic Cage Amines
• Facile Synthesis of Optically Active Tertiary Alcohol Building Blocks by Stereospecific C-H Insertion Reaction of Dichlorocarbene with Secondary Alcohol Derivatives.
• Asymmetric Synthesis of (+)-Dihydrokawain-5-ol.
• Facile Synthesis of Optically Active Tertiary Alcohol Building Blocks by Stereospecific C - H Insertion Reaction of Dichlorocarbene with Secondary Alcohol Derivatives
• The Synthesis, Molecular Structure and Selectivity of Macrotricyclic Ammonium-ion Receptor for Bromide Ion
• A highly asymmetric, Lewis Acid-catalysed Diels-Alder reaction using optically active 2-(3-tolyl-p-sulfinyl)furyl α, β-unsaturated ketones as a dienophile.
• Stereoselective Reduction of Chiral 3-(p-Tolylsulfinyl)-2-thienyl Ketones. : A Facile Entry to Optically Active Thienylcarbinols.
• Highly Stereoselective Hetero Diels-Alder Reactions of Chiral 3-(p-Tolylsulfinyl)-2-furaldehyde with Danishefsky's Diene Promoted by a Lanthanoid Lewis Acid.
• Stereoselective Reduction of Chiral 3-(p-Tolylsulfinyl)-2-thienyl Ketones. A Facile Entry to Optically Active Thienylcarbinols
• Diastereoselective Allylation of Chiral Sulfinyl-substituted Thiophenecarbaldehydes with a Lewis Acid.
• Nucleophilic Substituion Reaction of Optically Pure Chloroselenurane with Active Methylene Compounds. : Formation of Optically Pure Selenonium Ylides.
• Optically Pure Haloselenuranes. : First Synthesis and Nucleophilic Substitutions.
• Diels-Alder Reactions of Optically Active α-(2-exo-Hydroxy-10-bornylsulfinyl)-maleimides and its Application to Optically Active 5-Functionalised Pyrrolidines via Retro-Diels-Alder Reaction.
• Nucleophilic Substitution Reaction of Optically Pure Chloroselenurane with Active Methylene Compounds. Formation of Optically Pure Selenonium Ylides
• Total Synthesis of (+)-Asperlin Starting with (S, S)-Tartaric Acid.
• Total Synthesis of (+)-Asperlin Starting with (S,S)-Tartaric Acid
• Asymmetric Diels-Alder Cycloaddition with Chiral 2-Alkylsulfinyl-1-nitroalkenes.
• Addition-Elimination Strategy for Asymmetric Induction : A Chiral Sulfoxide as a Leaving Group.
• New Chiral Diphosphines, 2, 3-Bis(Siloxy)-1, 4-bis(diphenylphosphino)butanes, and Their Cationic Rh(I) Complexes : Synthesis and Structures
• Cyclization, Ring-Expansion, and Several Cascade Reactions Utilizing Allenylic Molecular Structure Characteristics
• 現状のままで満足ですか年輩者 : 今や集学的に"熟学"事始めの時
• 薬学教育における現行の問題点と21世紀への展望(21世紀の人づくり)(21世紀:薬学の時代へ)
• α-置換セリン誘導体の不斉合成
• 技術賞受賞抗血小板剤シロスタゾールの研究開発
• P-476 STEREOCHEMICAL COURSES IN TERMINATION OF TRITERPENE CYCLIZATION REACTION
• New Intramolecular Five-Endo-Mode Cyclization of Allenyl Aryl Ketones
• Generalization, Alteration, and Enhancement of the Stereoselectivity in the Cieplak-Mode Reductions of 4-Alkoxy(or Silyloxy)-cyclohexanones.
• New Reaction Mode of the Dieckmann-Type Cyclization under the Lewis Acid-Et_3N Conditions
• Asymmetric Horner-Wadsworth-Emmons Reaction Utilizing Isomannide and Isosorbide Derivatives as Chiral Auxiliaries
• ヘテロ原子の特性を活用する高立体選択的反応の開発 : HWE反応の新展開
• ヘテロ原子の特性を活用する高立体選択的反応の開発 : α置換セリン誘導体の不斉合成
• Crystal Structure of Dioctadecyldimethylammonium-Au(dmit)_2 Salt
• Helical Assembly Formed by Chiral [11]Thiaheterohelicene Molecules in Crystals. Architecture with Triple Helix
• Remarkable Effect of D-Sorbitol on the Second Stage in the PLE-Catalyzed Hydrolyses of a σ-Symmetric Diester, cis-Cyclohex-4-ene-1,2-bis(methyl acetate)
• First Synthesis and Reactivities of Isolable Dithiiranes and Their 1-Oxides
• Acyclic 1,2-Asymmetric Induction in Addition Reactions of Alkyl Radicals to Chiral Olefins
• Ion transfer at the interface between an aqueous solution in the presence of concentrated salts and an organic solution studied by polarography at the electrolyte solution dropping electrode
• Optically Active Cobalt(III) Complexes Containing Partial Cubane Co_3O_4 Core: Syntheses and Structures of the Isomers of [Co_3(L)_3(μ-OH)_3(μ_3-O)]Cl (L = Ethylenediamine-N-acetate)
• 新しいホスト分子の開発 : リン酸エステルの認識

もっと見る 閉じる

スポンサーリンク